The utility of serum neutrophil gelatinase-associated lipocalin level on predicting autosomal dominant polycystic kidney disease progression.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI:10.1111/1744-9987.14163

Cihan Uysal, Sumeyra Koyuncu, Funda Ipekten, Cigdem Karakukcu, Ismail Kocyigit

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Abstract

Introduction: We focused on neutrophil gelatinase-associated lipocalin (NGAL) and autosomal dominant polycystic kidney disease (ADPKD) progression.

Methods: ADPKD patients with an estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m² were included. Serum NGAL level and NGAL to eGFR ratio (NGR), height-adjusted total kidney volume (hTKV) were assessed initially. Patients were followed-up for 5 years.

Results: Sixty one patients were enrolled and initial eGFR was 73.6 (48.9-101.5) ml/min/1.73m². EGFR declined by 3.7 mL/min/1.73m² per year. Thirty four patients (55.7%) exhibited rapid progression. Rapid progression group had lower serum NGAL levels (p < 0.001) and higher hTKV (p < 0.001). Lower serum NGAL level was a risk factor for rapid progression (p < 0.001). NGR was not associated with rapid progression. Serum NGAL level was predictive in for rapid progression ROC analysis (cut-off <10.62 ng/mL).

Conclusion: Relatively lower serum NGAL levels can predict worse outcomes in ADPKD and can provide risk stratification in patients with ADPKD.

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血清中性粒细胞明胶酶相关脂联素水平对预测常染色体显性多囊肾病进展的作用

简介：我们重点研究了中性粒细胞明胶酶相关脂质体蛋白（NGAL）和常染色体显性多囊肾（ADPKD）的进展：我们重点研究了中性粒细胞明胶酶相关脂联素（NGAL）与常染色体显性多囊肾病（ADPKD）的进展：纳入估计肾小球滤过率（eGFR）≥ 30 mL/min/1.73 m2的ADPKD患者。初步评估血清 NGAL 水平、NGAL 与 eGFR 比值（NGR）、身高调整后肾脏总体积（hTKV）。对患者进行了为期 5 年的随访：结果：61 名患者入选，初始 eGFR 为 73.6 (48.9-101.5) ml/min/1.73m2。EGFR 每年下降 3.7 毫升/分钟/1.73 平方米。34名患者（55.7%）表现为快速进展。快速进展组患者的血清 NGAL 水平较低（p 结论：快速进展组患者的血清 NGAL 水平相对较低：相对较低的血清 NGAL 水平可预测 ADPKD 患者较差的预后，并可对 ADPKD 患者进行风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

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