Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents: a systematic review and meta-analysis.

IF 6.1 2区 医学 Q1 PEDIATRICS
World Journal of Pediatrics Pub Date : 2024-06-01 Epub Date: 2024-05-21 DOI:10.1007/s12519-024-00814-1
Eun Joo Lee, Miyoung Choi, Sang Bong Ahn, Jeong-Ju Yoo, Seong Hee Kang, Yuri Cho, Do Seon Song, Hong Koh, Dae Won Jun, Hye Won Lee
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引用次数: 0

Abstract

Background: As childhood obesity escalates worldwide, the prevalence of nonalcoholic fatty liver disease (NAFLD) in pediatric and adolescent populations is also increasing. However, systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain limited.

Methods: The MEDLINE, Korean Medical Database (KMBASE), Embase, Global Health, and Cochrane Library databases were searched from January 1997 to April 2023. Search terms included NAFLD or steatosis; nonalcoholic or steatohepatitis; child(ren), adolescent, or teenager; and prevalence, incidence, or epidemiology. A random-effects meta-analysis model was used to estimate the prevalence of pediatric NAFLD.

Results: A total of 2116 publications were found, of which 62 were included in the meta-analysis. Among them, 27 reported the prevalence in the general population and 39 in the obese population. The worldwide pooled prevalence of pediatric NAFLD was 13% [95% confidence interval (CI) 9-18%] in the general population and 47% (95% CI 41%-53%) in the obese population. Among 16 studies in the general population and 18 in the obese population, NAFLD prevalence varied by gender. In the general population, the prevalence of NAFLD was 15% (95% CI 8%-23%) in males and 10% (95% CI 6%-15%) in females. In the obese population, it was 54% (95% CI 46%-61%) in males and 39% (95% CI 30%-49%) in females.

Conclusions: The global prevalence of pediatric NAFLD is rising in both the general and obese populations. Given the increasing rates of childhood obesity, epidemiological studies on the prevalence and incidence of NAFLD are needed.

Abstract Image

儿科和青少年非酒精性脂肪肝的患病率:系统回顾和荟萃分析。
背景:随着全球儿童肥胖症的增加,非酒精性脂肪肝(NAFLD)在儿科和青少年人群中的发病率也在增加。然而,评估小儿非酒精性脂肪肝发病率的系统研究和荟萃分析仍然有限:方法:检索了 1997 年 1 月至 2023 年 4 月期间的 MEDLINE、韩国医学数据库 (KMBASE)、Embase、Global Health 和 Cochrane 图书馆数据库。检索词包括非酒精性脂肪肝或脂肪变性;非酒精性或脂肪性肝炎;儿童、青少年或少年;流行率、发病率或流行病学。采用随机效应荟萃分析模型估算小儿非酒精性脂肪肝的患病率:结果:共找到 2116 篇文献,其中 62 篇被纳入荟萃分析。其中,27篇报告了普通人群的患病率,39篇报告了肥胖人群的患病率。全球汇总的小儿非酒精性脂肪肝患病率为:普通人群 13% [95% 置信区间 (CI) 9-18%],肥胖人群 47% (95% CI 41%-53%)。在针对普通人群的 16 项研究和针对肥胖人群的 18 项研究中,非酒精性脂肪肝的患病率因性别而异。在普通人群中,男性非酒精性脂肪肝的患病率为15%(95% CI为8%-23%),女性为10%(95% CI为6%-15%)。在肥胖人群中,男性为54%(95% CI 46%-61%),女性为39%(95% CI 30%-49%):结论:无论在普通人群还是肥胖人群中,小儿非酒精性脂肪肝的全球发病率都在上升。鉴于儿童肥胖率不断上升,需要对非酒精性脂肪肝的患病率和发病率进行流行病学研究。
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来源期刊
World Journal of Pediatrics
World Journal of Pediatrics 医学-小儿科
CiteScore
10.50
自引率
1.10%
发文量
592
审稿时长
2.5 months
期刊介绍: The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics. We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
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