Correlations of FCGR2A 131R/H and FCGR3A 158V/F Polymorphisms with the Susceptibility of Peri-implantitis in Chinese Han Population.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biotechnology Pub Date : 2025-06-01 Epub Date: 2024-05-21 DOI:10.1007/s12033-024-01193-8

Peng Li, Bingzhuo Chen, Liang Zhao, Feng Yang, Zhu Zhang, Yuan Cao, Yang Hu

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Abstract

The purpose of the study is to investigate the relationship of peri-implantitis (PI) with FCGR2A and FCGR3A gene polymorphisms. One hundred and forty-four patients with PI and 136 patients without PI infection were selected. Gingival crevicular fluid samples were collected from the two groups. The FCGR2A and FCGR3A polymorphism in the two groups were measured. All volunteers were evaluated for periodontal status. The effect of polymorphisms on PI susceptibility was investigated by chi-square analysis and logistic regression. The frequency of FCGR2A rs1801274 GG genotype of PI group was higher than that of the control group, while the GA and AA genotype carriers were less in PI group. After adjusting for other clinical indicators, rs1801274 GA genotype, AA genotype, and the A allele were still negatively correlated with the onset of PI. FCGR3A rs396991 polymorphism was not associated with PI. FCGR2A rs1801274 polymorphism was significantly associated with PI in the Chinese Han population, and GG genotype might be a genetic risk factor for PI.

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中国汉族人群中 FCGR2A 131R/H 和 FCGR3A 158V/F 多态性与种植体周围炎易感性的相关性

本研究旨在探讨种植体周围炎（PI）与 FCGR2A 和 FCGR3A 基因多态性的关系。研究选取了 144 名 PI 患者和 136 名未感染 PI 的患者。收集了两组患者的牙龈细缝液样本。测量两组患者的 FCGR2A 和 FCGR3A 基因多态性。对所有志愿者的牙周状况进行评估。通过卡方分析和逻辑回归研究了多态性对 PI 易感性的影响。PI组中FCGR2A rs1801274 GG基因型的频率高于对照组，而PI组中GA和AA基因型携带者较少。调整其他临床指标后，rs1801274 GA 基因型、AA 基因型和 A 等位基因仍与 PI 发病呈负相关。FCGR3A rs396991 多态性与 PI 无关。在中国汉族人群中，FCGR2A rs1801274多态性与PI显著相关，GG基因型可能是PI的遗传风险因素。

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来源期刊

Molecular Biotechnology 医学-生化与分子生物学

CiteScore

4.10

自引率

3.80%

发文量

165

审稿时长

6 months

期刊介绍： Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.