Effect of Cold Adaptation on the State of Cardiovascular System and Cardiac Tolerance to Ischemia/Reperfusion Injury.

Q2 Biochemistry, Genetics and Molecular Biology

Iranian Biomedical Journal Pub Date : 2024-03-01 DOI:10.61186/ibj.3872

Nikita S Voronkov, Sergey V Popov, Natalia V Naryzhnaya, N Rajendra Prasad, Ivan M Petrov, Viktor V Kolpakov, Evgenia A Tomilova, Ekaterina V Sapozhenkova, Leonid N Maslov

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Abstract

Despite the unconditional success achieved in the treatment and prevention of AMI over the past 40 years, mortality in this disease remains high. Hence, it is necessary to develop novel drugs with mechanism of action different from those currently used in clinical practices. Studying the molecular mechanisms involved in the cardioprotective effect of adapting to cold could contribute to the development of drugs that increase cardiac tolerance to the impact of ischemia/reperfusion. An analysis of the published data shows that the long-term human stay in the Far North contributes to the occurrence of cardiovascular diseases. At the same time, chronic and continuous exposure to cold increases tolerance of the rat heart to ischemia/ reperfusion. It has been demonstrated that the cardioprotective effect of cold adaptation depends on the activation of ROS production, stimulation of the β2-adrenergic receptor and protein kinase C, MPT pore closing, and KATP channel.

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冷适应对心血管系统状态和心脏对缺血再灌注损伤耐受性的影响

尽管在过去 40 年中，急性心肌梗死的治疗和预防取得了无条件的成功，但这种疾病的死亡率仍然很高。因此，有必要开发作用机制不同于目前临床所用药物的新型药物。研究适应寒冷的心脏保护作用所涉及的分子机制，有助于开发能增强心脏对缺血/再灌注影响的耐受性的药物。对已发表数据的分析表明，人类长期居住在极北地区会导致心血管疾病的发生。同时，长期持续暴露在寒冷环境中会增加大鼠心脏对缺血/再灌注的耐受性。研究表明，寒冷适应对心脏的保护作用取决于 ROS 生成的激活、β2-肾上腺素能受体和蛋白激酶 C 的刺激、MPT 孔关闭和 KATP 通道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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