Polydopamine-modified black phosphorus nanosheet drug delivery system for the treatment of ischemic stroke.

IF 5.6 1区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Regenerative Biomaterials Pub Date : 2024-05-02 eCollection Date: 2024-01-01 DOI:10.1093/rb/rbae046
Shujiang Yin, Jing Hou, Jie Li, Caiyun Zeng, Shuang Chen, Han Zhang, Xing Tian
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引用次数: 0

Abstract

Black phosphorus (BP), as a representative metal-free semiconductor, has been extensively explored. It has a higher drug loading capacity in comparison to conventional materials and also possesses excellent biocompatibility and biodegradability. Furthermore, BP nanosheets can enhance the permeability of the blood-brain barrier (BBB) upon near-infrared (NIR) irradiation, owing to their photothermal effect. However, the inherent instability of BP poses a significant limitation, highlighting the importance of surface modification to enhance its stability. Ischemic stroke (IS) is caused by the occlusion of blood vessels, and its treatment is challenging due to the hindrance caused by the BBB. Therefore, there is an urgent need to identify improved methods for bypassing the BBB for more efficient IS treatment. This research devised a novel drug delivery approach based on pterostilbene (Pte) supported by BP nanosheets, modified with polydopamine (PDA) to form BP-Pte@PDA. This system shows robust stability and traverses the BBB using effective photothermal mechanisms. This enables the release of Pte upon pH and NIR stimuli, offering potential therapeutic advantages for treating IS. In a middle cerebral artery occlusion mouse model, the BP-Pte@PDA delivery system significantly reduced infarct size, and brain water content, improved neurological deficits, reduced the TLR4 inflammatory factor expression, and inhibited cell apoptosis. In summary, the drug delivery system fabricated in this study thus demonstrated good stability, therapeutic efficacy, and biocompatibility, rendering it suitable for clinical application.

用于治疗缺血性中风的聚多巴胺改性黑磷纳米片给药系统。
黑磷(BP)作为一种具有代表性的无金属半导体,已经得到了广泛的研究。与传统材料相比,它具有更高的药物负载能力,同时还具有良好的生物相容性和生物降解性。此外,由于其光热效应,BP 纳米片在近红外(NIR)照射下可增强血脑屏障(BBB)的渗透性。然而,BP 固有的不稳定性是一个重要的限制因素,这突出了表面改性以提高其稳定性的重要性。缺血性中风(IS)是由血管闭塞引起的,由于 BBB 的阻碍,其治疗具有挑战性。因此,迫切需要找到绕过 BBB 的改良方法,以更有效地治疗缺血性中风。本研究设计了一种基于紫檀芪(Pte)的新型给药方法,该方法由 BP 纳米片支撑,并用聚多巴胺(PDA)修饰形成 BP-Pte@PDA。该系统显示出强大的稳定性,并能利用有效的光热机制穿越 BBB。这使得 Pte 在 pH 值和近红外刺激下得以释放,为治疗 IS 提供了潜在的治疗优势。在大脑中动脉闭塞小鼠模型中,BP-Pte@PDA 给药系统明显缩小了梗塞面积,降低了脑水含量,改善了神经功能缺损,减少了 TLR4 炎症因子的表达,抑制了细胞凋亡。总之,本研究制备的给药系统具有良好的稳定性、治疗效果和生物相容性,适合临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Regenerative Biomaterials
Regenerative Biomaterials Materials Science-Biomaterials
CiteScore
7.90
自引率
16.40%
发文量
92
审稿时长
10 weeks
期刊介绍: Regenerative Biomaterials is an international, interdisciplinary, peer-reviewed journal publishing the latest advances in biomaterials and regenerative medicine. The journal provides a forum for the publication of original research papers, reviews, clinical case reports, and commentaries on the topics relevant to the development of advanced regenerative biomaterials concerning novel regenerative technologies and therapeutic approaches for the regeneration and repair of damaged tissues and organs. The interactions of biomaterials with cells and tissue, especially with stem cells, will be of particular focus.
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