Co-administration of resveratrol rescued lead-induced toxicity in Drosophila melanogaster

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-05-18 DOI:10.1016/j.etap.2024.104470

R. Abdulazeez , S.M. Highab , U.F. Onyawole , M.T. Jeje , H. Musa , D.M. Shehu , I.S. Ndams

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Abstract

Lead toxicity poses a significant environmental concern linked to diverse health issues. This study explores the potential mitigating effects of resveratrol on lead-induced toxicity in Drosophila melanogaster. Adult fruit flies, aged three days, were orally exposed to lead (60 mg/L), Succimer (10 mg), and varying concentrations of resveratrol (50, 100, and 150 mg). The investigation encompassed the assessment of selected biological parameters, biochemical markers, oxidative stress indicators, and antioxidant enzymes. Resveratrol exhibited a dose-dependent enhancement of egg-laying, eclosion rate, filial generation output, locomotor activity, and life span in D. melanogaster, significantly to 150 mg of diet. Most of the investigated biochemical parameters were significantly rescued in lead-exposed fruit flies when co-treated with resveratrol (p < 0.05). However, oxidative stress remained unaffected by resveratrol. The findings suggest that resveratrol effectively protects against lead toxicity in Drosophila melanogaster and may hold therapeutic potential as an agent for managing lead poisoning in humans.

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联合施用白藜芦醇可缓解黑腹果蝇铅诱导的毒性。

铅毒性是一个与多种健康问题相关的重大环境问题。本研究探讨了白藜芦醇对黑腹果蝇铅毒性的潜在缓解作用。将成年果蝇（3 天龄）口服铅（60 毫克/升）、琥珀酰亚胺（10 毫克）和不同浓度的白藜芦醇（50、100 和 150 毫克）。调查包括对选定生物参数、生化指标、氧化应激指标和抗氧化酶的评估。白藜芦醇对黑腹蝇蛆的产卵率、孵化率、子代产量、运动活性和寿命都有剂量依赖性的提高，显著提高到150毫克日粮的水平。与白藜芦醇联合处理后，铅暴露果蝇的大多数生化指标都有明显改善（p < 0.05）。然而，氧化应激仍然不受白藜芦醇的影响。研究结果表明，白藜芦醇能有效防止黑色果蝇的铅中毒，并有可能成为控制人类铅中毒的治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.