Deficits in brain glucose transport among younger adults with obesity

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-05-19 DOI:10.1002/oby.24034

Felona Gunawan, Brooke C. Matson, Anastasia Coppoli, Lihong Jiang, Yuyan Ding, Rachel Perry, Elizabeth Sanchez-Rangel, Renata Belfort DeAguiar, Kevin L. Behar, Douglas L. Rothman, Graeme F. Mason, Janice J. Hwang

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引用次数: 0

Abstract

Objective

Obesity is associated with alterations in eating behavior and neurocognitive function. In this study, we investigate the effect of obesity on brain energy utilization, including brain glucose transport and metabolism.

Methods

A total of 11 lean participants and 7 young healthy participants with obesity (mean age, 27 years) underwent magnetic resonance spectroscopy scanning coupled with a hyperglycemic clamp (target, ~180 mg/dL) using [1-¹³C] glucose to measure brain glucose uptake and metabolism, as well as peripheral markers of insulin resistance.

Results

Individuals with obesity demonstrated an ~20% lower ratio of brain glucose uptake to cerebral glucose metabolic rate (T_max/CMR_glucose) than lean participants (2.12 ± 0.51 vs. 2.67 ± 0.51; p = 0.04). The cerebral tricarboxylic acid cycle flux (V_TCA) was similar between the two groups (p = 0.64). There was a negative correlation between total nonesterified fatty acids and T_max/CMR_glucose (r = −0.477; p = 0.045).

Conclusions

We conclude that CMR_glucose is unlikely to differ between groups due to similar V_TCA, and, therefore, the glucose transport T_max is lower in individuals with obesity. These human findings suggest that obesity is associated with reduced cerebral glucose transport capacity even at a young age and in the absence of other cardiometabolic comorbidities, which may have implications for long-term brain function and health.

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患有肥胖症的年轻成年人大脑葡萄糖转运功能存在缺陷。

目的：肥胖症与饮食行为和神经认知功能的改变有关：肥胖与饮食行为和神经认知功能的改变有关。在这项研究中，我们探讨了肥胖对大脑能量利用的影响，包括大脑葡萄糖转运和代谢：共有 11 名瘦弱的参与者和 7 名肥胖的年轻健康参与者（平均年龄 27 岁）接受了磁共振波谱扫描和使用 [1-13C] 葡萄糖的高血糖钳夹（目标值约 180 毫克/分升），以测量脑葡萄糖摄取和代谢以及外周胰岛素抵抗标志物：结果：肥胖者的脑葡萄糖摄取与脑葡萄糖代谢率（Tmax/CMRglucose）之比（2.12 ± 0.51 vs. 2.67 ± 0.51; p = 0.04）比瘦者低约 20%。两组的大脑三羧酸循环通量（VTCA）相似（p = 0.64）。总非酯化脂肪酸与 Tmax/CMRglucose 之间呈负相关（r = -0.477；p = 0.045）：我们得出结论：由于 VTCA 相似，不同组间的 CMR 葡萄糖不太可能存在差异，因此肥胖症患者的葡萄糖转运 Tmax 较低。这些人类研究结果表明，肥胖与脑葡萄糖转运能力降低有关，即使肥胖者年龄较轻且没有其他心脏代谢合并症，这可能会对大脑的长期功能和健康产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.