Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis.

Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia Pub Date : 2024-04-09 eCollection Date: 2024-01-01 DOI:10.61622/rbgo/2024rbgo31

Andreia Jacobo, Renata Fogaça Borges, Carlos Augusto Bastos de Souza, Vanessa Krebs Genro, João Sabino Cunha-Filho

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Abstract

Objective: To compare Transforming growth factor beta-1 (TGF-β1) expression in patients with and without adenomyosis.

Methods: A prospective design was performed including 49 patients submitted to hysterectomy. Immunohistochemistry was performed on anatomopathological samples staged in paraffin blocks from patients with and without adenomyosis. The sample contained 28 adenomyosis cases and 21 controls. Student's t-test and multivariate logistic regression tests were used for statistical analysis. Associations were considered significant at p < 0.05.

Results: We found no significant association between adenomyosis and: smoking (p = 0.75), miscarriage (p = 0.29), number of previous pregnancies (p = 0.85), curettage (p = 0.81), pelvic pain (p = 0.72) and myoma (p = 0.15). However, we did find a relationship between adenomyosis and abnormal uterine bleeding (AUB) (p = 0.02) and previous cesarean section (p = 0.02). The mean TGF-β1 intensity (mean ± SD) in the ectopic endometrium of women with adenomyosis showed no significant association (184.17 ± 9.4 vs.184.66 ± 16.08, p = 0.86) from the topic endometrium of women without adenomyosis.

Conclusion: TGF-β1 expression was not increased in the ectopic endometrium of women with adenomyosis.

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子宫腺肌症患者体内转化生长因子β-1（TGF-β1）的表达。

摘要比较子宫腺肌症患者和非子宫腺肌症患者体内转化生长因子β1（TGF-β1）的表达情况：方法：对49名接受子宫切除术的患者进行前瞻性设计。对患有和未患有子宫腺肌症的患者的石蜡块解剖病理样本进行了免疫组化。样本中包括 28 例腺肌症病例和 21 例对照病例。统计分析采用了学生 t 检验和多变量逻辑回归检验。结果显示，P < 0.05 为相关性显著：我们发现子宫腺肌症与以下因素无明显关系：吸烟（p = 0.75）、流产（p = 0.29）、前次怀孕次数（p = 0.85）、刮宫（p = 0.81）、盆腔疼痛（p = 0.72）和肌瘤（p = 0.15）。不过，我们确实发现子宫腺肌症与异常子宫出血（AUB）（p = 0.02）和既往剖宫产（p = 0.02）之间存在关系。患有子宫腺肌症的妇女异位子宫内膜的平均 TGF-β1 强度（平均值 ± SD）与未患有子宫腺肌症的妇女异位子宫内膜的平均 TGF-β1 强度（184.17 ± 9.4 vs. 184.66 ± 16.08，P = 0.86）无明显关联：结论：TGF-β1在子宫腺肌症妇女异位子宫内膜中的表达没有增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia

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