The Neutrophil to Lymphocyte Ratio Modifies Lipoprotein (a)-Related Poor Prognosis in Patients After Percutaneous Coronary Intervention.

IF 2.2 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Angiology Pub Date : 2025-10-01 Epub Date: 2024-05-19 DOI:10.1177/00033197241255414

Zhangyu Lin, Jining He, Chenxi Song, Rui Zhang, Sheng Yuan, Xiaohui Bian, Kefei Dou

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引用次数: 0

Abstract

Lipoprotein (a) [Lp(a)] could contribute to coronary artery disease (CAD) through proinflammatory effects. The neutrophil to lymphocyte ratio (NLR) is an inflammatory biomarker. We consecutively enrolled 7,922 CAD patients to investigate the synergistic association of Lp(a) and NLR with prognosis in patients undergoing percutaneous coronary intervention (PCI). NLR was calculated as the neutrophil count divided by the lymphocyte count. Cutoff for NLR was a median of 2.07. The threshold value was set at 30 mg/dL for Lp(a). The primary endpoint was major adverse cardiac events (MACEs), including all-cause mortality and myocardial infarction. During 2 years follow-up, 111 (1.40%) MACEs occurred. Lp(a) > 30 mg/dL was associated with an increased MACE risk in participants with NLR ≥2.07 [adjusted hazard ratio (HR), 1.84; 95% CI, 1.12-3.03], but not in participants with NLR <2.07 (adjusted HR, 0.74; 95% CI, 0.38-1.45) (P_interaction = 0.021). Subgroup analysis demonstrated that the synergistic association of Lp(a) and NLR with prognosis was more pronounced in female patients (P_interaction = 0.028). This study suggested that combining Lp(a) and NLR may be useful for risk stratification in CAD population.

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中性粒细胞与淋巴细胞比率可改变经皮冠状动脉介入术后患者与脂蛋白 (a) 相关的不良预后。

脂蛋白（a）[Lp（a）]可通过促炎作用导致冠状动脉疾病（CAD）。中性粒细胞与淋巴细胞比值（NLR）是一种炎症生物标志物。我们连续招募了 7922 名 CAD 患者，研究 Lp(a) 和 NLR 与接受经皮冠状动脉介入治疗（PCI）患者预后的协同关系。NLR 的计算方法是中性粒细胞计数除以淋巴细胞计数。NLR 的临界值为中位数 2.07。脂蛋白（a）的临界值设定为 30 mg/dL。主要终点是主要心脏不良事件（MACE），包括全因死亡率和心肌梗死。在 2 年的随访期间，共发生 111 例（1.40%）MACE。在 NLR≥2.07 的参与者中，Lp(a) > 30 mg/dL 与 MACE 风险增加有关[调整后危险比 (HR)，1.84；95% CI，1.12-3.03]，但在 NLR Pinteraction = 0.021 的参与者中则无关。）亚组分析表明，Lp（a）和 NLR 与预后的协同关系在女性患者中更为明显（Pinteraction = 0.028）。这项研究表明，结合 Lp(a) 和 NLR 可能有助于对 CAD 患者进行风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days