Per-polyfluoroalkyl substances (PFAS) as thyroid disruptors: is there evidence for multi-transgenerational effects?

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM

Expert Review of Endocrinology & Metabolism Pub Date : 2024-07-01 Epub Date: 2024-05-19 DOI:10.1080/17446651.2024.2351885

Francesca Coperchini, Marsida Teliti, Alessia Greco, Laura Croce, Mario Rotondi

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引用次数: 0

Abstract

Introduction: The environmental spread of pollutants has led to a persistent exposure of living beings to multiple chemicals, by now become ubiquitous in the surrounding environment. Environmental exposure to these substances has been reported to cause multi- and/or transgenerational health effects. Per- and Polyfluorinated Substances (PFAS) raise great concern, given their known effects both as endocrine disruptors and potential carcinogens. The multi/trans-generational effects of different endocrine disruptors have been investigated by several studies, and harmful effects observed also for PFAS.

Areas covered: This review examines the current data on the multi-trans-generational effects of PFAS, with a focus on their impact on the thyroid axis. The aim is to determine if there is evidence of potential multi-trans-generational effects of PFAS on the thyroid and/or if more research is needed.

Expert opinion: PFAS exposure impacts thyroid homeostasis and can cross the placental barrier. In addition PFAS have shown multi-transgenerational effects in laboratory experiences and animal models, but thyroid disruptive effects of PFAS were also investigated only in a small number of these studies. Efforts are needed to study the adverse effects of PFAS, as not all PFAS are regulated and removal strategies are still being developed.

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作为甲状腺干扰物的全氟烷基物质（PFAS）：是否有证据表明存在多代效应？

引言污染物在环境中的扩散导致生物持续暴露于多种化学物质，现在这些化学物质已在周围环境中无处不在。据报道，在环境中接触这些物质会造成多代和/或跨代的健康影响。全氟和多氟化合物（PFAS）作为内分泌干扰物和潜在的致癌物质，引起了人们的极大关注。多项研究已经对不同内分泌干扰物的多代/跨代影响进行了调查，并观察到 PFAS 也有有害影响：本综述研究了有关全氟辛烷磺酸多代/跨代影响的现有数据，重点关注其对甲状腺轴的影响。目的是确定是否有证据表明PFAS可能对甲状腺产生跨代影响，以及/或者是否需要开展更多研究：专家观点：PFAS 暴露会影响甲状腺稳态，并可穿过胎盘屏障。此外，全氟辛烷磺酸在实验室经验和动物模型中显示出了多代效应，但这些研究中只有少数研究了全氟辛烷磺酸对甲状腺的破坏性影响。由于并非所有的全氟辛烷磺酸都受到管制，而且清除战略仍在制定中，因此需要努力研究全氟辛烷磺酸的不利影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

自引率

0.00%

发文量

期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.