Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis.

IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

International journal of clinical and experimental medicine Pub Date : 2015-08-15 eCollection Date: 2015-01-01

Yingdong Lian, Zhijun Tang, Yuxi Xie, Zongxiang Chen

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Abstract

Objective: To assess the relationship between the polymorphisms of leptin receptor gene and hypertension.

Methods: Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein".

Results: Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertension patients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertension patients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91).

Conclusion: Gln223Arg, but not Lys109Arg gene polymorphism, is higher in hypertension patients, suggesting that patients with Gln223Arg allele carry a higher risk to develop hypertension.

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瘦素受体基因多态性与高血压风险：一项荟萃分析。

目的：评估瘦素受体基因多态性与高血压之间的关系：评估瘦素受体基因多态性与高血压之间的关系：使用 RevMan 5.3 进行 Meta 分析。以 "高血压"、"瘦素受体"、"OB 受体"、"LEPR 蛋白 "为关键词在 PubMed 上检索相关文献：本次荟萃分析共纳入了 15 项研究，涉及 5955 名高血压患者和 3830 名健康对照者。结果显示，高血压患者的 Gln223Arg 基因多态性明显高于对照组（OR=1.36，95% CI=1.23-1.51，PConclusion：高血压患者中Gln223Arg基因多态性较高，而Lys109Arg基因多态性较低，这表明Gln223Arg等位基因患者患高血压的风险较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of clinical and experimental medicine MEDICINE, RESEARCH & EXPERIMENTAL-

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