Nanodiamonds as Lutetium-177 Carriers for Nuclear Medicine

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Radiochemistry Pub Date : 2024-05-16 DOI:10.1134/S1066362224020085

A. G. Kazakov, J. S. Babenya, T. Y. Ekatova, S. E. Vinokurov, E. Y. Khvorostinin, I. A. Ushakov, V. V. Zukau, E. S. Stasyuk, E. A. Nesterov, V. L. Sadkin, A. S. Rogov, B. F. Myasoedov

引用次数: 0

Abstract

The work investigated the sorption of no-carrier-added ¹⁷⁷Lu isolated from neutron-irradiated ¹⁷⁶Yb₂O₃, and carrier-added ¹⁷⁷Lu obtained by irradiation of ^natLu₂O₃, by commercial and oxidized nanodiamonds (NDs) of various grades from aqueous solutions to identify among them a promising carrier for further research in the field of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP grade (ox-STP); conditions for the fast sorption of lutetium with it in an amount equivalent to 1.2 GBq of no-carrier-added ¹⁷⁷Lu were determined, which corresponds to the activity used in therapy.

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用作核医学镥 177 载体的纳米金刚石

摘要这项工作研究了从中子辐照 176Yb2O3 分离出的无载体添加的 177Lu 和通过辐照 natLu2O3 获得的载体添加的 177Lu 在水溶液中被不同等级的商用和氧化纳米金刚石（NDs）吸附的情况，以便从中找出一种有前途的载体，用于核医学领域的进一步研究。结果发现了一种很有前途的吸附剂：STP 级氧化纳米金刚石（ox-STP）；确定了用它快速吸附镥的条件，吸附量相当于 1.2 GBq 的无载体添加 177Lu，这与治疗中使用的活性相符。

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.