The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of 90Y and 177Lu Isotopes for Further Use in Nuclear Medicine

IF 0.9 Q4 CHEMISTRY, INORGANIC & NUCLEAR

Radiochemistry Pub Date : 2024-05-16 DOI:10.1134/s1066362224020097

A. G. Kazakov, J. S. Babenya, T. Y. Ekatova, S. E. Vinokurov, E. Y. Khvorostinin, I. A. Ushakov, V. V. Zukau, E. S. Stasyuk, E. A. Nesterov, V. L. Sadkin, A. S. Rogov, B. F. Myasoedov

引用次数: 0

Abstract

Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for the use in nuclear medicine. In this work, we investigated the influence of the properties of NDs suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes ⁹⁰Y and ¹⁷⁷Lu and determination of conditions for fabricating promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the NDs surface, while the forms of cations of the studied nuclides in the solution do not affect the sorption value.

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悬浮液中纳米金刚石聚集体的尺寸对进一步用于核医学的 90Y 和 177Lu 同位素吸附效率的影响

摘要纳米金刚石（NDs）是放射性药物中很有前途的放射性核素载体，可用于核医学。在这项工作中，我们研究了不同 pH 值的水溶液中纳米金刚石悬浮液的性质（包括其聚集体的大小）对其与医用同位素 90Y 和 177Lu 结合的影响，并确定了为进一步的体内研究制造有前景的共轭物的条件。研究表明，吸附力受溶液成分的影响，溶液成分决定了玖龙表面的特性，而所研究的核素在溶液中的阳离子形式并不影响吸附值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiochemistry CHEMISTRY, INORGANIC & NUCLEAR-

CiteScore

1.30

自引率

33.30%

发文量

期刊介绍： Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.