Plasmonic biosensors: Towards fully operative detection platforms for biomedical application and its potential for the diagnosis of autoimmune diseases
Juliana Fátima Giarola, M.- Carmen Estevez, Laura M. Lechuga
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引用次数: 0
Abstract
In-vitro diagnostics (IVD) has become an in-demand area with a high-achievement transformation due to the expansion of new technologies. Technology has grown from time-consuming laboratory techniques to modern automated immunoassays and progressed with real-time sensing through the emergence of biosensor devices. Plasmonic biosensors are one of the most employed optical biosensors and stand out for their versatility and wide range of applications in diagnostic tests. One of the clinical diagnostics areas of growing interest is autoimmune diseases (AD), which have been increasingly prevalent worldwide. There is a rising demand for reliable and early AD diagnosis tools. This review highlights the main challenges for early AD diagnostics and the advanced plasmonic biosensors that have been exploited for AD biomarker detection, including brief descriptions of their analytical performance. Finally, the prospects and trends in this area are outlined, thinking about developing multiplexed platforms capable of addressing the multianalyte nature of one disease.
随着新技术的发展,体外诊断(IVD)已成为一个需求旺盛、成果转化率高的领域。技术已从耗时的实验室技术发展到现代化的自动免疫测定,并通过生物传感器设备的出现实现了实时传感。质子生物传感器是最常用的光学生物传感器之一,因其多功能性和在诊断测试中的广泛应用而脱颖而出。自身免疫性疾病(AD)是人们日益关注的临床诊断领域之一,这种疾病在全球的发病率越来越高。对可靠的早期 AD 诊断工具的需求日益增长。本综述重点介绍了早期 AD 诊断面临的主要挑战,以及已用于 AD 生物标记物检测的先进等离子体生物传感器,包括对其分析性能的简要说明。最后,概述了这一领域的前景和趋势,并对开发能够解决一种疾病的多分析物特性的复用平台进行了思考。
期刊介绍:
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.