Graphene quantum dots (GQDs)-modified screen-printed electrode for the determination of cannabidiol (CBD) in hemp seeds flour

IF 5.9 3区材料科学 Q2 CHEMISTRY, PHYSICAL

FlatChem Pub Date : 2024-05-13 DOI:10.1016/j.flatc.2024.100673

Khouloud Abid , Angelo Ferlazzo , Giovanni Neri

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Abstract

In this work, the development of a graphene quantum dots (GQDs)-modified screen-printed carbon (SPCE) electrode for the determination of cannabidiol (CBD), a cannabinoid present in the Cannabis L. Sativa (hemp) plant, is reported. This cannabinoid is non-intoxicating and non-psychoactive, thus CBD-containing drugs as well as CBD-containing foods, are now on the market in many countries due to their health-beneficial effects and pharmacological activities. Because of the increasing interest in analyzing CBD in these real samples, we analyzed here a sample of hemp flour that was used for testing the developed CBD electrochemical sensor. Preliminary work devoted to optimizing the analysis conditions, allowed to development of a GQDs-modified electrode with promising characteristics for the simple screening of CBD. The electroanalytical tests for CBD detection showed a sensitivity of 0.98 μAμM^-1 cm⁻², which is increased by 2-folder compared to bare SPCE, and a limit of detection (LOD) equal to 0.277 μM. The developed GQDs/SPCE sensor and the analysis procedure were then applied for the CBD analysis in a hemp seeds flour sample. Based on the results obtained, the advantages/disadvantages evidenced by operating with the developed electrochemical sensor in the analysis of CBD in real samples were discussed.

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石墨烯量子点 (GQDs) 改性丝网印刷电极用于测定大麻籽粉中的大麻二酚 (CBD)

本研究报告了石墨烯量子点（GQDs）修饰的丝网印刷碳（SPCE）电极的开发情况，该电极用于测定大麻二酚（CBD），这是一种存在于大麻（Cannabis L. Sativa）植物中的大麻素。这种大麻素不具毒性和精神活性，因此，由于其有益健康的作用和药理活性，含 CBD 的药物和含 CBD 的食品现已在许多国家上市。由于人们对分析这些真实样品中的 CBD 越来越感兴趣，我们在此分析了用于测试所开发的 CBD 电化学传感器的大麻粉样品。在优化分析条件的前期工作中，我们开发出了一种 GQDs 修饰电极，它具有简单筛选 CBD 的良好特性。检测 CBD 的电分析测试结果表明，灵敏度为 0.98 μAμM-1 cm-2，与裸 SPCE 相比提高了 2 倍，检出限（LOD）为 0.277 μM。开发的 GQDs/SPCE 传感器和分析程序随后被应用于大麻籽面粉样品中的 CBD 分析。根据所获得的结果，讨论了在实际样品中使用所开发的电化学传感器分析 CBD 的优缺点。

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来源期刊

FlatChem Multiple-

CiteScore

8.40

自引率

6.50%

发文量

104

审稿时长

26 days

期刊介绍： FlatChem - Chemistry of Flat Materials, a new voice in the community, publishes original and significant, cutting-edge research related to the chemistry of graphene and related 2D & layered materials. The overall aim of the journal is to combine the chemistry and applications of these materials, where the submission of communications, full papers, and concepts should contain chemistry in a materials context, which can be both experimental and/or theoretical. In addition to original research articles, FlatChem also offers reviews, minireviews, highlights and perspectives on the future of this research area with the scientific leaders in fields related to Flat Materials. Topics of interest include, but are not limited to, the following: -Design, synthesis, applications and investigation of graphene, graphene related materials and other 2D & layered materials (for example Silicene, Germanene, Phosphorene, MXenes, Boron nitride, Transition metal dichalcogenides) -Characterization of these materials using all forms of spectroscopy and microscopy techniques -Chemical modification or functionalization and dispersion of these materials, as well as interactions with other materials -Exploring the surface chemistry of these materials for applications in: Sensors or detectors in electrochemical/Lab on a Chip devices, Composite materials, Membranes, Environment technology, Catalysis for energy storage and conversion (for example fuel cells, supercapacitors, batteries, hydrogen storage), Biomedical technology (drug delivery, biosensing, bioimaging)