The effect of fish oil rich in cetoleic acid on the omega-3 index and skin quality

IF 3
D. Tobin , L.K. Midtbø , J. Mildenberger , H. Svensen , I. Stoknes
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引用次数: 0

Abstract

Objective: The objective of the study was to provide preliminary data on the effect of a long chain monounsaturated oil rich in cetoleic acid on the omega-3 index, a validated measure of EPA and DHA in blood cells, as well as a potential effect of the oil on skin quality.

Design: Two intervention studies were performed, each as double blinded, placebo controlled, randomised nutritional trials. The CetoIndex study (N = 55) measured omega-3 index using a blood spot collection kit (Omegaquant). The Optihud study (N = 28) measured skin quality parameters in healthy women using the VISIA system. The cetoleic-rich-oil (CRO) was an oil derived from North Atlantic fish with a predominance of long chain mono-unsaturated fatty acids including cetoleic acid (C22:1 n-11) and gondoic acid (C20:1 n-9).

Results: In a placebo-controlled study, the omega-3 index in healthy volunteers was increased similar to that seen with an oil with higher levels of omega-3 fatty acids. In a separate placebo-controlled study, the CRO reduced erythema in skin, which is a marker of inflammation.

Conclusions: The results of this pilot study suggest that the use of a CRO increases the omega-3 index more than expected from the levels of EPA and DHA in the oil. The CRO may potentially have benefits on skin inflammation.

Summary: Long chain polyunsaturated fatty acids (LCPUFA), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are commonly taken as dietary supplements for a range of health benefits. Other marine fatty acids may also provide health benefits and it is of interest to understand their activity. Long chain mono-unsaturated fatty acids (LCMUFA) have shown biological activity in studies of metabolic health in animal models. Here, we report two intervention studies using a fish oil with a high LCMUFA content where cetoleic acid is the predominant fatty acid (Cetoleic rich oil: CRO). In CetoIndex, a placebo-controlled study in 55 healthy volunteers, the omega-3 index increased similarly to that seen with an oil containing higher levels of omega-3 fatty acids. In Optihud, a placebo-controlled study in 28 female volunteers, the CRO reduced erythema in skin, which is a marker of inflammation. The results of this pilot study support the use of a CRO for increasing the omega-3 index with potential benefits on skin inflammation.

富含鲸蜡油酸的鱼油对欧米茄-3 指数和皮肤质量的影响
研究目的该研究旨在提供初步数据,说明富含鲸蜡油酸的长链单不饱和油对欧米伽-3 指数(血细胞中 EPA 和 DHA 的有效测量指标)的影响,以及该油对皮肤质量的潜在影响:进行了两项干预研究,每项研究都是双盲、安慰剂对照、随机营养试验。CetoIndex研究(N = 55)使用血斑采集试剂盒(Omegaquant)测量欧米伽-3指数。Optihud 研究(28 人)使用 VISIA 系统测量健康女性的皮肤质量参数。鲸蜡油(CRO)是从北大西洋鱼类中提取的一种油,主要含有长链单不饱和脂肪酸,包括鲸蜡酸(C22:1 n-11)和贡多拉酸(C20:1 n-9):在一项安慰剂对照研究中,健康志愿者体内的欧米伽-3指数与欧米伽-3脂肪酸含量较高的油中的欧米伽-3指数相似。在另一项安慰剂对照研究中,CRO减少了皮肤红斑,而红斑是炎症的标志:这项试点研究的结果表明,使用 CRO 增加的欧米伽-3 指数高于从油中的 EPA 和 DHA 含量所预期的水平。总结:长链多不饱和脂肪酸(LCPUFA),尤其是二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),通常作为膳食补充剂服用,对健康有一系列益处。其他海洋脂肪酸也可能对健康有益,了解它们的活性很有意义。长链单不饱和脂肪酸(LCMUFA)在动物模型代谢健康研究中显示出生物活性。在这里,我们报告了两项使用 LCMUFA 含量较高的鱼油进行干预的研究,其中鲸蜡油酸是主要脂肪酸(富含鲸蜡油酸的鱼油:CRO)。CetoIndex 是一项在 55 名健康志愿者中进行的安慰剂对照研究,在这项研究中,omega-3 指数的增加情况与含有较高omega-3 脂肪酸的鱼油相似。在对 28 名女性志愿者进行的安慰剂对照研究 Optihud 中,CRO 减少了皮肤红斑,而红斑是炎症的标志。这项试验研究的结果支持使用 CRO 来提高欧米加-3 指数,从而对皮肤炎症产生潜在的益处。
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来源期刊
Prostaglandins, leukotrienes, and essential fatty acids
Prostaglandins, leukotrienes, and essential fatty acids Clinical Biochemistry, Endocrinology, Diabetes and Metabolism
CiteScore
5.30
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0.00%
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审稿时长
64 days
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