Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-05-18 DOI:10.1080/00397911.2024.2346565

F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim

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引用次数: 0

Abstract

The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions 4 was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (1). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor 4 with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound 4 with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds 7, 12 and 14. The synthesized products were inferred using analytical and spectral data.

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新型环状铬[3',2':5,6]吡啶并[2,3- d ][1,3,4]噻二唑并[3,2- a ]嘧啶和铬[3'',2'':5',6']吡啶并[2',3':4,5]嘧啶并[2,1- b ][1,3,4]噻二嗪：合成方法和抗菌效率

目前的研究包括一些含有铬酮分子的线性杂环化合物的合成方法。以 6,8-二甲基铬酮-3-甲腈（1）为起始原料，高效合成了具有氨基硫酮功能的铬并吡啶嘧啶 4。通过将关键前体 4 与一些单亲电试剂缩合，合成了新型铬吡啶噻二唑嘧啶。此外，通过化合物 4 与一些α-卤代羰基试剂缩合，合成了杂化的铬吡啶嘧啶噻二嗪类化合物。对合成产物的抗菌效率进行了检测，结果表明其对受检微生物具有显著的活性，尤其是化合物 7、12 和 14。利用分析和光谱数据对合成产物进行了推断。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.