F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim
{"title":"Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency","authors":"F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim","doi":"10.1080/00397911.2024.2346565","DOIUrl":null,"url":null,"abstract":"<div><p>The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions <strong>4</strong> was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (<strong>1</strong>). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor <strong>4</strong> with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound <strong>4</strong> with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds <strong>7</strong>, <strong>12</strong> and <strong>14</strong>. The synthesized products were inferred using analytical and spectral data.</p></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 10","pages":"Pages 843-852"},"PeriodicalIF":1.8000,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthetic Communications","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S0039791124000377","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions 4 was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (1). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor 4 with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound 4 with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds 7, 12 and 14. The synthesized products were inferred using analytical and spectral data.
期刊介绍:
Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.