{"title":"Xiao-Yao-San Improves Sleep Quality in Insomnia Patients With and Without Moderate-to-Severe Obstructive Sleep Apnoea—A Pilot Polysomnography Study","authors":"Y.-C. Hsu , Y.-H. Zhu , C.-Y. Hsu , Y.-R. Chen , Y.-T. Tsai","doi":"10.1016/j.hermed.2024.100893","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>This single-arm pilot study aimed to investigate the effects of a 1-month Xiao-Yao-San (<strong>XYS</strong>) treatment with on objective and subjective sleep parameters among insomnia patients with and without moderate-to-severe obstructive sleep apnea (<strong>OSA</strong>)</p></div><div><h3>Methods</h3><p>This single-arm pre-post study included fourteen participants (average age, 48.2±15.5 years). All participants received <strong>XYS</strong> (3 g × 3 times/day, after meals) for 28 days. Among them, 7 participants had an apnea-hypopnea index (<strong>AHI</strong>) ≥15 events/hour and were classified as having moderate-to-severe OSA, while 7 patients had an <strong>AHI</strong> <15 events/hour Polysomnography was performed to evaluate the AHI, sleep stage, sleep efficiency, and sleep latency at the beginning and after 28 days of usage. Subjective questionnaires were also administered, including the Pittsburgh Sleep Quality Index (<strong>PSQI</strong>), Hospital Anxiety and Depression Scale (HADS-A and HADS-D), and Epworth Sleepiness Scale (<strong>ESS</strong>). The Wilcoxon test was used to compare the pre-treatment and post-treatment differences</p></div><div><h3>Results</h3><p>Our 14 insomnia participants, with an average AHI of 21.2 events/hour at baseline who were taking XYS, exhibited a statistically significant reduction in PSQI scores (reduction of −3.0; <em>P</em> = 0.002) compared with the corresponding baseline values. The objective sleep evaluations did not show differences between participants with or without moderate-to-severe OSA after receiving XYS treatment. For subjective sleep parameters, only participants without moderate-to-severe OSA exhibited statistically significant improvements in sleep quality (PSQI score pretest/posttest: 10.0±3.5/7.0±3.5; <em>P</em> = 0.012).</p></div><div><h3>Conclusions</h3><p>XYS treatment may significantly improve sleep quality in participants without moderate-to-severe OSA. Further studies with larger sample sizes and longer durations are needed.</p></div>","PeriodicalId":56077,"journal":{"name":"Journal of Herbal Medicine","volume":"46 ","pages":"Article 100893"},"PeriodicalIF":2.2000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Herbal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210803324000502","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction
This single-arm pilot study aimed to investigate the effects of a 1-month Xiao-Yao-San (XYS) treatment with on objective and subjective sleep parameters among insomnia patients with and without moderate-to-severe obstructive sleep apnea (OSA)
Methods
This single-arm pre-post study included fourteen participants (average age, 48.2±15.5 years). All participants received XYS (3 g × 3 times/day, after meals) for 28 days. Among them, 7 participants had an apnea-hypopnea index (AHI) ≥15 events/hour and were classified as having moderate-to-severe OSA, while 7 patients had an AHI <15 events/hour Polysomnography was performed to evaluate the AHI, sleep stage, sleep efficiency, and sleep latency at the beginning and after 28 days of usage. Subjective questionnaires were also administered, including the Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS-A and HADS-D), and Epworth Sleepiness Scale (ESS). The Wilcoxon test was used to compare the pre-treatment and post-treatment differences
Results
Our 14 insomnia participants, with an average AHI of 21.2 events/hour at baseline who were taking XYS, exhibited a statistically significant reduction in PSQI scores (reduction of −3.0; P = 0.002) compared with the corresponding baseline values. The objective sleep evaluations did not show differences between participants with or without moderate-to-severe OSA after receiving XYS treatment. For subjective sleep parameters, only participants without moderate-to-severe OSA exhibited statistically significant improvements in sleep quality (PSQI score pretest/posttest: 10.0±3.5/7.0±3.5; P = 0.012).
Conclusions
XYS treatment may significantly improve sleep quality in participants without moderate-to-severe OSA. Further studies with larger sample sizes and longer durations are needed.
期刊介绍:
The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.