Prevention of diabetes from prediabetes in real world setting in South India

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-05-01 DOI:10.1016/j.dsx.2024.103041

Vijay Viswanathan, Premalatha Murugan, Satyavani Kumpatla, Rizwana Parveen, Arutselvi Devarajan

{"title":"Prevention of diabetes from prediabetes in real world setting in South India","authors":"Vijay Viswanathan, Premalatha Murugan, Satyavani Kumpatla, Rizwana Parveen, Arutselvi Devarajan","doi":"10.1016/j.dsx.2024.103041","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><p>The aim was to explore the effect of lifestyle modification in a real world situation to prevent the progression to diabetes in India.</p></div><div><h3>Methods</h3><p>Participants who underwent OGTT from August 2017–2022 and were diagnosed as having Prediabetes (n = 200) were assigned into control (group1, n = 100) received standard care and intervention (group2, n = 100) received intensive counseling on physical activity (PA) and diet. PA included walking for 150 min/week and personalized advice based on the profession. OGTTs were repeated once every 6 months for 5 years and primary outcome was development of DM.</p></div><div><h3>Results</h3><p>The conversion rate was significantly higher in the control group than the intervention group (44.6 vs.7.9 %, p < 0.0001). Individuals who reverted back to normal was significantly higher in Group2 compared to Group1 (34.9 vs.6.2 %; p < 0.001). A significant increase in weight, BMI and waist circumference in group1 and significant reduction in glucose and HbA1c was noted in group2. Mean (95%CI) survival time for Group1 was 25.4 (20.8–29.9) and Group2 was 36.4months (32.6–40.1; p < 0.001). The factors which influenced the conversion of prediabetes to DM were averaged BMI, fasting and 2hr glucose levels of all follow up visit measurements.</p></div><div><h3>Conclusion</h3><p>We can prevent diabetes in individuals with prediabetes using real world strategies in India.</p></div>","PeriodicalId":48252,"journal":{"name":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","volume":"18 5","pages":"Article 103041"},"PeriodicalIF":4.3000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & Metabolic Syndrome-Clinical Research & Reviews","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1871402124001024","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

The aim was to explore the effect of lifestyle modification in a real world situation to prevent the progression to diabetes in India.

Methods

Participants who underwent OGTT from August 2017–2022 and were diagnosed as having Prediabetes (n = 200) were assigned into control (group1, n = 100) received standard care and intervention (group2, n = 100) received intensive counseling on physical activity (PA) and diet. PA included walking for 150 min/week and personalized advice based on the profession. OGTTs were repeated once every 6 months for 5 years and primary outcome was development of DM.

Results

The conversion rate was significantly higher in the control group than the intervention group (44.6 vs.7.9 %, p < 0.0001). Individuals who reverted back to normal was significantly higher in Group2 compared to Group1 (34.9 vs.6.2 %; p < 0.001). A significant increase in weight, BMI and waist circumference in group1 and significant reduction in glucose and HbA1c was noted in group2. Mean (95%CI) survival time for Group1 was 25.4 (20.8–29.9) and Group2 was 36.4months (32.6–40.1; p < 0.001). The factors which influenced the conversion of prediabetes to DM were averaged BMI, fasting and 2hr glucose levels of all follow up visit measurements.

Conclusion

We can prevent diabetes in individuals with prediabetes using real world strategies in India.

查看原文本刊更多论文

在南印度的现实环境中，从糖尿病前期预防糖尿病。

方法将 2017 年 8 月至 2022 年期间接受 OGTT 并被诊断为糖尿病前期的参与者（n = 200）分为对照组（第 1 组，n = 100）和干预组（第 2 组，n = 100），对照组接受标准护理，干预组接受体育锻炼（PA）和饮食方面的强化咨询。体力活动包括每周步行 150 分钟，并根据专业提供个性化建议。结果对照组的转阴率明显高于干预组（44.6% 对 7.9%，P < 0.0001）。与第一组相比，第二组恢复正常的人数明显较多（34.9% 对 6.2%；p <0.001）。第一组的体重、体重指数和腰围明显增加，第二组的血糖和 HbA1c 明显降低。第一组的平均（95%CI）存活时间为 25.4 个月（20.8-29.9），第二组为 36.4 个月（32.6-40.1；p < 0.001）。影响糖尿病前期转化为糖尿病的因素是所有随访测量的平均体重指数、空腹血糖和 2 小时血糖水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.