Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2024-06-01 DOI:10.1016/j.jacbts.2024.02.014

Shijie Liu PhD , Vaibhav Deshmukh PhD , Fangfei Wang MD , Jie Liang MS , Jenna Cusick BS , Xiao Li PhD , James F. Martin MD, PhD

引用次数: 0

Abstract

Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level. Identifying heart cell proteomes and their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked protein synthesis after myocardial infarction. Our results showed that myocardial infarction suppresses protein synthesis and unveils a decoupling of translation and transcription regulation in cardiomyocytes.

Abstract Image

查看原文本刊更多论文

心肌梗死抑制蛋白质合成并导致转录和翻译脱钩

基因表达包括转录、翻译、mRNA 和蛋白质降解。先进的 RNA 测序技术可测量 mRNA 水平以评估细胞状态，但 mRNA 水平并不能完全反映蛋白质水平。识别心脏细胞蛋白质组及其应激反应至关重要。利用心肌细胞特异性小鼠模型，我们追踪了心肌梗死后的蛋白质合成情况。我们的研究结果表明，心肌梗死抑制了蛋白质的合成，并揭示了心肌细胞中翻译和转录调控的脱钩。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.