Age-specific analysis of anti-müllerian hormone and liver biochemical parameters in freemartin holstein calves and heifers: A pilot study

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Gokhan Bozkurt , Feyyaz Kaya , Mehmet Yildiz , Sultan Sengul , Ismail Ilker Kocaer , Halil Erkan Sarıbas , Orsan Gungor , Ibrahim Tasal , Yigit Can Aslan , Serdar Dursun Ak , Afsin Koker
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Abstract

Freemartinism is the most common congenital anomaly among sexual disorders in dairy cows. This syndrome typically occurs in different-sex twin pregnancies and causes vascular anastomoses to form with the placenta in the early stages of fetal development. The study aims to determine the effectiveness of Anti-müllerian hormone (AMH) levels in calves and heifers of different age groups for diagnostic factors and to investigate the potential consequences of different hormone levels in different age groups on some liver biochemical parameters. The study involved 50 cattle from diverse age categories, divided into the freemartin group (FM Group, n=25) and the control group (C Group, n=25). Both FM and control groups were further divided into early-age (3-5 months), middle-aged (5-9 months), and older-aged groups (9-12 months). Serum AMH levels, along with total protein, albumin, and total cholesterol levels, were measured. While no statistically significant difference in AMH levels was observed in the early-age group (P:0.53), significant differences were determined in the middle (P:0.015) and older-age groups (P:0.01), where the FM group exhibited significantly decreased AMH levels compared to the control group. The evaluation of liver biochemistry revealed a statistically significant difference in total protein levels between the FM and control groups in the older age group (P:0.033). Consequently, it is reasonable to suggest that AMH levels may serve as a valid parameter for diagnosing freemartin syndrome in calves aged older than five months. Conversely, particularly in young calves, no significant differences in liver functionality were observed between freemartin-affected and healthy calves.

自由马丁荷斯坦犊牛和小母牛抗苗勒管激素和肝脏生化参数的年龄特异性分析:一项试点研究
自由软骨症是奶牛性功能障碍中最常见的先天性畸形。这种综合征通常发生在异性双胎妊娠中,会导致胎儿发育早期与胎盘形成血管吻合。本研究旨在确定不同年龄组犊牛和小母牛体内抗苗勒管激素(AMH)水平对诊断因素的有效性,并调查不同年龄组不同激素水平对某些肝脏生化指标的潜在影响。研究涉及 50 头不同年龄段的牛,分为自由马丁组(FM 组,n=25)和对照组(C 组,n=25)。FM 组和对照组又分为早龄组(3-5 个月)、中龄组(5-9 个月)和老龄组(9-12 个月)。测量血清 AMH 水平以及总蛋白、白蛋白和总胆固醇水平。虽然早期组的 AMH 水平没有明显的统计学差异(P:0.53),但中期组(P:0.015)和高龄组(P:0.01)的差异明显,其中调频组的 AMH 水平与对照组相比明显下降。对肝脏生化指标的评估显示,在老年组中,调频组和对照组的总蛋白水平差异有统计学意义(P:0.033)。因此,我们有理由认为,AMH 水平可作为诊断 5 个月以上犊牛的自由马丁综合征的有效参数。相反,特别是在年轻犊牛中,未观察到受弗氏综合征影响的犊牛和健康犊牛的肝功能有明显差异。
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来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
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