Neural correlates of stress-reactive rumination in depression – The role of childhood trauma and social anxiety

IF 4.3 2区 医学 Q1 NEUROSCIENCES
David Rosenbaum , Isabell Int-Veen , Hendrik Laicher , Leonie Woloszyn , Ariane Wiegand , Sandra Ladegast , Ute Eßer , Agnes Kroczek , Daniel Sippel , Sebastian Menkor , Glenn Lawyer , Francesco Albasini , Christian Frischholz , Rainald Mössner , Vanessa Nieratschker , Elisabeth J. Leehr , Julian Rubel , Andreas J. Fallgatter , Ann-Christine Ehlis
{"title":"Neural correlates of stress-reactive rumination in depression – The role of childhood trauma and social anxiety","authors":"David Rosenbaum ,&nbsp;Isabell Int-Veen ,&nbsp;Hendrik Laicher ,&nbsp;Leonie Woloszyn ,&nbsp;Ariane Wiegand ,&nbsp;Sandra Ladegast ,&nbsp;Ute Eßer ,&nbsp;Agnes Kroczek ,&nbsp;Daniel Sippel ,&nbsp;Sebastian Menkor ,&nbsp;Glenn Lawyer ,&nbsp;Francesco Albasini ,&nbsp;Christian Frischholz ,&nbsp;Rainald Mössner ,&nbsp;Vanessa Nieratschker ,&nbsp;Elisabeth J. Leehr ,&nbsp;Julian Rubel ,&nbsp;Andreas J. Fallgatter ,&nbsp;Ann-Christine Ehlis","doi":"10.1016/j.ynstr.2024.100640","DOIUrl":null,"url":null,"abstract":"<div><p>Recent work showed an association of prefrontal dysfunctions in patients with Major Depressive Disorder (MDD) and social stress induced rumination. However, up to date it is unclear which etiological features of MDD might cause prefrontal dysfunctions. In the study at hand, we aimed to replicate recent findings, that showed prefrontal activation alterations during the Trier Social Stress Test (TSST) and subsequently increased stress-reactive rumination in MDD compared to healthy controls. Moreover, we aimed to explore the role of adverse childhood experiences and other clinical variables in this relationship. N = 55 patients currently suffering from MDD and n = 42 healthy controls (HC) underwent the TSST, while cortical activity in areas of the Cognitive Control Network (CCN) was measured via functional near-infrared spectroscopy (fNIRS). The TSST successfully induced a stress reaction (physiologically, as well as indicated by subjective stress ratings) and state rumination in all subjects with moderate to large effect sizes. In comparison to HC, MDD patients showed elevated levels of state rumination with large effect sizes, as well as a typical pattern of reduced cortical oxygenation during stress in the CCN with moderate effect sizes. Self-reported emotional abuse and social anxiety were moderately positively associated with increased stress-reactive rumination. Within the MDD sample, emotional abuse was negatively and social anxiety positively associated with cortical oxygenation within the CCN with moderate to large effect sizes. In conclusion, our results replicate previous findings on MDD-associated prefrontal hypoactivity during stress and extends the research toward specific subtypes of depression.</p></div>","PeriodicalId":19125,"journal":{"name":"Neurobiology of Stress","volume":"31 ","pages":"Article 100640"},"PeriodicalIF":4.3000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352289524000365/pdfft?md5=a1d875ff9ce6b9cc8590e86b1628ebad&pid=1-s2.0-S2352289524000365-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobiology of Stress","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352289524000365","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Recent work showed an association of prefrontal dysfunctions in patients with Major Depressive Disorder (MDD) and social stress induced rumination. However, up to date it is unclear which etiological features of MDD might cause prefrontal dysfunctions. In the study at hand, we aimed to replicate recent findings, that showed prefrontal activation alterations during the Trier Social Stress Test (TSST) and subsequently increased stress-reactive rumination in MDD compared to healthy controls. Moreover, we aimed to explore the role of adverse childhood experiences and other clinical variables in this relationship. N = 55 patients currently suffering from MDD and n = 42 healthy controls (HC) underwent the TSST, while cortical activity in areas of the Cognitive Control Network (CCN) was measured via functional near-infrared spectroscopy (fNIRS). The TSST successfully induced a stress reaction (physiologically, as well as indicated by subjective stress ratings) and state rumination in all subjects with moderate to large effect sizes. In comparison to HC, MDD patients showed elevated levels of state rumination with large effect sizes, as well as a typical pattern of reduced cortical oxygenation during stress in the CCN with moderate effect sizes. Self-reported emotional abuse and social anxiety were moderately positively associated with increased stress-reactive rumination. Within the MDD sample, emotional abuse was negatively and social anxiety positively associated with cortical oxygenation within the CCN with moderate to large effect sizes. In conclusion, our results replicate previous findings on MDD-associated prefrontal hypoactivity during stress and extends the research toward specific subtypes of depression.

抑郁症患者压力反应性反刍的神经相关性--童年创伤和社交焦虑的作用
最近的研究表明,重度抑郁症(MDD)患者的前额叶功能障碍与社会压力引起的反刍有关。然而,迄今为止,尚不清楚 MDD 的哪些病因特征可能会导致前额叶功能障碍。与健康对照组相比,特里尔社会压力测试(TSST)显示 MDD 患者在测试过程中前额叶激活发生改变,随后压力反应性反刍增加。此外,我们还旨在探索不良童年经历和其他临床变量在这种关系中的作用。55 名 MDD 患者和 42 名健康对照者(HC)接受了 TSST 测试,同时通过功能性近红外光谱(fNIRS)测量了认知控制网络(CCN)区域的皮层活动。TSST 成功地诱发了所有受试者的应激反应(生理反应以及主观应激评分)和状态反刍,并产生了中等到较大的效应量。与HC相比,MDD患者的状态反刍水平升高,影响程度较大;在CCN中,患者在应激时皮层氧合降低,影响程度中等。自我报告的情感虐待和社交焦虑与压力反应性反刍的增加呈中度正相关。在 MDD 样本中,情感虐待与 CCN 中的皮质氧合呈负相关,社交焦虑与 CCN 中的皮质氧合呈正相关,效应大小为中等到较大。总之,我们的研究结果重复了之前关于 MDD 相关前额叶在应激时活性低下的发现,并将研究扩展到了特定的抑郁症亚型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信