The correlation of ABC goal attainment with insulin resistance/sensitivity in Syrian type 2 diabetes patients

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Samer Younes
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引用次数: 0

Abstract

Background

The rising prevalence of type 2 diabetes (T2D) in Syria emphasizes the urgent requirement for effective management approaches. The ABC goals, which include maintaining glycated hemoglobin levels below 7 %, blood pressure below 140/90 mmHg, and low-density lipoprotein cholesterol levels below 100 mg/dl, serve as crucial benchmarks for managing T2D and its associated comorbidities.

Methods

In this cross-sectional study, the achievement of ABC goals was retrospectively examined among 681 clinically diagnosed T2D patients (not on Insulin) who participated in a six-year online lifestyle intervention program for diabetes management at the Freedom from Diabetes Clinic in Syria between January 2016 and December 2022.

Results

Out of the participants, 152 (22.3 %) successfully achieved all three ABC goals, while 306 (45.0 %) and 183 (26.9 %) achieved two or one goal(s) respectively. The factors influencing the attainment of all three ABC goals revealed a significant association with older age (>50 years), lower body mass index (<25 kg/m2), and lower insulin resistance (Homeostatic Model Assessment of Insulin Resistance < 2.5). Furthermore, patients who successfully achieved all three ABC goals exhibited lower insulin resistance, improved lipid profiles, and higher insulin sensitivity and beta cell function.

Conclusion

This study offers new insights into the relationship between insulin resistance/sensitivity and the achievement of ABC goals in the Syrian population with T2D, underscoring the necessity for tailored strategies to enhance comprehensive diabetes management.

叙利亚 2 型糖尿病患者 ABC 目标实现情况与胰岛素抵抗/敏感性的相关性。
背景叙利亚 2 型糖尿病(T2D)患病率不断上升,强调了对有效管理方法的迫切需求。ABC目标包括将糖化血红蛋白水平维持在7%以下、将血压维持在140/90 mmHg以下、将低密度脂蛋白胆固醇水平维持在100 mg/dl以下,这些目标是管理T2D及其相关合并症的重要基准。方法在这项横断面研究中,对 681 名临床确诊的 T2D 患者(未使用胰岛素)的 ABC 目标实现情况进行了回顾性研究,这些患者在 2016 年 1 月至 2022 年 12 月期间参加了叙利亚 Freedom from Diabetes 诊所为期六年的糖尿病管理在线生活方式干预项目。结果在参与者中,152 人(22.3%)成功实现了所有三个 ABC 目标,306 人(45.0%)和 183 人(26.9%)分别实现了两个或一个目标。影响实现所有三个 ABC 目标的因素显示,与年龄较大(50 岁)、体重指数较低(25 kg/m2)和胰岛素抵抗(胰岛素抵抗稳态模型评估 2.5)有关。此外,成功实现所有三个 ABC 目标的患者表现出较低的胰岛素抵抗、较好的血脂状况以及较高的胰岛素敏感性和 beta 细胞功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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