Brain reserve in midlife is associated with executive function changes across 12 years

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-05-16 DOI:10.1016/j.neurobiolaging.2024.05.001

Daniel E. Gustavson , Jeremy A. Elman , Chandra A. Reynolds , Lisa T. Eyler , Christine Fennema-Notestine , Olivia K. Puckett , Matthew S. Panizzon , Nathan A. Gillespie , Michael C. Neale , Michael J. Lyons , Carol E. Franz , William S. Kremen

{"title":"Brain reserve in midlife is associated with executive function changes across 12 years","authors":"Daniel E. Gustavson , Jeremy A. Elman , Chandra A. Reynolds , Lisa T. Eyler , Christine Fennema-Notestine , Olivia K. Puckett , Matthew S. Panizzon , Nathan A. Gillespie , Michael C. Neale , Michael J. Lyons , Carol E. Franz , William S. Kremen","doi":"10.1016/j.neurobiolaging.2024.05.001","DOIUrl":null,"url":null,"abstract":"<div>We examined how brain reserve in midlife, measured by brain-predicted age difference scores (Brain-PADs), predicted executive function concurrently and longitudinally into early old age, and whether these associations were moderated by young adult cognitive reserve or APOE genotype. 508 men in the Vietnam Era Twin Study of Aging (VETSA) completed neuroimaging assessments at mean age 56 and six executive function tasks at mean ages 56, 62, and 68 years. Results indicated that greater brain reserve at age 56 was associated with better concurrent executive function (r=.10, p=.040) and less decline in executive function over 12 years (r=.34, p=.001). These associations were not moderated by cognitive reserve or APOE genotype. Twin analysis suggested associations with executive function slopes were driven by genetic influences. Our findings suggest that greater brain reserve allowed for better cognitive maintenance from middle- to old age, driven by a genetic association. The results are consistent with differential preservation of executive function based on brain reserve that is independent of young adult cognitive reserve or APOE genotype.</div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 113-120"},"PeriodicalIF":3.7000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobiology of Aging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0197458024000927","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

We examined how brain reserve in midlife, measured by brain-predicted age difference scores (Brain-PADs), predicted executive function concurrently and longitudinally into early old age, and whether these associations were moderated by young adult cognitive reserve or APOE genotype. 508 men in the Vietnam Era Twin Study of Aging (VETSA) completed neuroimaging assessments at mean age 56 and six executive function tasks at mean ages 56, 62, and 68 years. Results indicated that greater brain reserve at age 56 was associated with better concurrent executive function (r=.10, p=.040) and less decline in executive function over 12 years (r=.34, p=.001). These associations were not moderated by cognitive reserve or APOE genotype. Twin analysis suggested associations with executive function slopes were driven by genetic influences. Our findings suggest that greater brain reserve allowed for better cognitive maintenance from middle- to old age, driven by a genetic association. The results are consistent with differential preservation of executive function based on brain reserve that is independent of young adult cognitive reserve or APOE genotype.

查看原文本刊更多论文

中年时期的大脑储备与 12 年间的执行功能变化有关

我们研究了以大脑预测年龄差异分数（Brain-PADs）衡量的中年大脑储备如何同时和纵向预测进入老年早期的执行功能，以及这些关联是否受年轻成人认知储备或 APOE 基因型的调节。越战时期双生子衰老研究（VETSA）中的 508 名男性在平均 56 岁时完成了神经影像评估，并在平均 56、62 和 68 岁时完成了六项执行功能任务。结果表明，56 岁时大脑储备量越大，同时执行功能越好（r=.10，p=.040），12 年后执行功能下降越小（r=.34，p=.001）。这些关联不受认知储备或 APOE 基因型的影响。双胞胎分析表明，与执行功能斜率的关联是由遗传因素驱动的。我们的研究结果表明，在遗传因素的驱动下，大脑储备越多，认知能力从中年到老年就能得到更好的维持。这些结果与大脑储备对执行功能的不同保护是一致的，而这与年轻成人的认知储备或APOE基因型无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.