Within-person fluctuations of fatigue in patients with a clinical diagnosis of systemic sclerosis and its relationship with mood, pain, sleep and physical activity

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-02 DOI:10.1177/23971983241242836

A. Velauthapillai, M. Vonk, Cornelia H M van den Ende, Johanna E. Vriezekolk

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Abstract

To explore the within-person fluctuations of fatigue in systemic sclerosis and its association with negative affect, positive affect, pain, perceived exertion of physical activity and quality of sleep. We performed an ecological momentary assessment study in adult patients with a clinical diagnosis of systemic sclerosis. During 14 days, patients completed daily assessments of fatigue severity, negative affect, positive affect, pain, quality of sleep and perceived exertion of physical activity at four fixed time points. The day-to-day fluctuations in fatigue were quantified by the intra-individual variance and probability of acute change, capturing the magnitude and frequency of clinical relevant within-person day-to-day fluctuations, respectively. Using multilevel models, the within-person association between fatigue and the daily assessments were analysed. Fifty-seven patients with systemic sclerosis participated. The mean (standard deviation) intra-individual variance was 1.08 (0.42) and the probability of acute change was mean (standard deviation) 0.40 (0.14), ranging from 0.08 to 0.77. For fatigue, a within-person variation of 51% was observed. Multilevel analyses showed that higher average levels and daily increases in negative affect, pain and perceived exertion of physical activity were associated with more fatigue, while the opposite was observed for positive affect and quality of sleep. Positive affect demonstrated the strongest association with fatigue fluctuations. This is the first quantitative study showing that fatigue in systemic sclerosis is characterized by a dynamic course and that approximately half of the day-to-day fluctuations within persons are clinically meaningful. Furthermore, our results indicate that integrating activities with positive impact on mood into fatigue treatment strategies might reduce the frequency of fatigue fluctuations.

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临床诊断为系统性硬化症患者的人际疲劳波动及其与情绪、疼痛、睡眠和体力活动的关系

目的：探讨系统性硬化症患者疲劳在人体内的波动及其与消极情绪、积极情绪、疼痛、体力活动消耗感和睡眠质量的关系。我们对临床诊断为系统性硬化症的成年患者进行了一项生态学瞬间评估研究。在 14 天内，患者每天在四个固定时间点完成对疲劳严重程度、消极情绪、积极情绪、疼痛、睡眠质量和体力活动消耗感知的评估。疲劳的日常波动通过个体内方差和急性变化概率进行量化，分别捕捉与临床相关的人体内日常波动的幅度和频率。使用多层次模型分析了疲劳与日常评估之间的人际关联。57名系统性硬化症患者参加了此次研究。个体内部差异的平均值（标准差）为 1.08 (0.42)，急性变化概率的平均值（标准差）为 0.40 (0.14)，范围在 0.08 至 0.77 之间。在疲劳方面，观察到的人内差异为 51%。多层次分析表明，消极情绪、疼痛和体力活动消耗感的平均水平越高、每天增加的幅度越大，疲劳感就越强，而积极情绪和睡眠质量则与之相反。积极情绪与疲劳波动的关系最为密切。这是第一项定量研究，它表明系统性硬化症患者的疲劳具有动态过程的特点，而且在患者的日常波动中，约有一半具有临床意义。此外，我们的研究结果表明，将对情绪有积极影响的活动纳入疲劳治疗策略中可能会降低疲劳波动的频率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.