Effects of zinc supplementation and implant abscess on the immune system and growth performance of growing beef steers

IF 1.3 Q3 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Translational Animal Science Pub Date : 2024-05-02 DOI:10.1093/tas/txae075

Emma L Rients, Carlos E Franco, Fabian Diaz, Jodi McGill, Stephanie L. Hansen

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Abstract

Abstract Seventy-two Angus-cross steers (261 ± 14 kg) were utilized to determine the effects of supplemental Zn sulfate on growth, trace mineral status, circulating immune cells, and functional innate immune responses. Steers were stratified by weight and implanted with a Component E-S with Tylan implant (Elanco Animal Health, Greenfield, IN) on day 0. Dietary treatments included: control (CON; no supplemental Zn), Zn100 (100 mg supplemental Zn/kg DM), and Zn150 (150 mg supplemental Zn/kg DM). Analyzed dietary concentrations of Zn were 58, 160, and 207 mg Zn/kg DM, respectively. On days 13 and 57, blood from nine steers per treatment was collected for immune analyses (cell phenotyping and response to stimulus). On day 16, implant abscesses were evaluated by palpation and visual appraisal. Sixty percent of steers had abscesses; however, there were no differences in abscess prevalence due to treatment (P = 0.67). Data were analyzed as a split-plot design using the Mixed procedure of SAS 9.4 (Cary, NC) with effects of dietary treatment, abscess, and their interaction. There was a tendency (treatment × abscess; P ≤ 0.09) for steers without abscesses to have greater average daily gain (ADG; treatment × abscess P = 0.06) and gain:feed (G:F; treatment × abscess P = 0.09) from d 14 to 27 in CON and Zn100 while within Zn150 steers without abscesses tended to have lesser ADG and G:F than abscessed steers. There were no other treatment × abscess effects for growth performance, but steers with abscesses tended to have decreased final body weight (P = 0.10) and overall G:F (days 0 to 57; P = 0.08). There was no interaction of treatment and abscess on immune cell populations on days 13 or 58 (treatment × abscess P ≥ 0.11). On day 13, Zn150 steers had increased CD45RO + gamma delta (P = 0.04) T cells. Abscessed steers had increased CD21 + B cells (P = 0.03) and tended to have increased CD21 + (P = 0.07) and CD21 + MHCIIhi (P = 0.07) B cells in circulation. This study shows zinc supplementation and implant abscesses can alter the immune system and growth performance of growing beef steers.

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补锌和植入脓肿对生长肉牛免疫系统和生长性能的影响

摘要我们利用 72 头安格斯杂交母牛（261 ± 14 千克）来确定补充硫酸锌对生长、微量矿物质状态、循环免疫细胞和功能性先天性免疫反应的影响。按体重对母牛进行分层，并在第 0 天植入含泰然成分的 E-S 植入物（Elanco Animal Health, Greenfield, IN）。日粮处理包括：对照组（CON；不补充锌）、Zn100（100 毫克补充锌/千克 DM）和 Zn150（150 毫克补充锌/千克 DM）。分析得出的日粮锌浓度分别为 58、160 和 207 毫克锌/千克 DM。第 13 天和第 57 天，收集每个处理九头公牛的血液进行免疫分析（细胞表型和对刺激的反应）。第 16 天，通过触诊和目测评估植入脓肿。60%的公牛出现了脓肿；但是，脓肿发生率并没有因治疗方法而产生差异（P = 0.67）。使用 SAS 9.4（北卡罗来纳州凯里市）的混合程序对数据进行了分割图设计分析，其中包括日粮处理、脓肿及其交互作用的影响。在 CON 和 Zn100 中，从第 14 天到第 27 天，没有脓肿的母牛的平均日增重（ADG；处理×脓肿 P = 0.06）和增重：饲料（G:F；处理×脓肿 P = 0.09）有增加的趋势（处理×脓肿；P ≤ 0.09），而在 Zn150 中，没有脓肿的母牛的 ADG 和 G:F 往往低于脓肿母牛。在生长性能方面，没有其他处理×脓肿的效应，但有脓肿的阉牛最终体重（P = 0.10）和总体G:F（第0天至第57天；P = 0.08）往往下降。在第 13 天或第 58 天，处理和脓肿对免疫细胞群没有交互作用（处理 × 脓肿 P ≥ 0.11）。第 13 天，Zn150 牛的 CD45RO + γ delta（P = 0.04）T 细胞增加。脓肿母牛的 CD21 + B 细胞增加（P = 0.03），循环中的 CD21 + (P = 0.07) 和 CD21 + MHCIIhi (P = 0.07) B 细胞也趋于增加。这项研究表明，补锌和植入脓肿可改变生长肉牛的免疫系统和生长性能。

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来源期刊

Translational Animal Science Veterinary-Veterinary (all)

CiteScore

2.80

自引率

15.40%

发文量

149

审稿时长

8 weeks

期刊介绍： Translational Animal Science (TAS) is the first open access-open review animal science journal, encompassing a broad scope of research topics in animal science. TAS focuses on translating basic science to innovation, and validation of these innovations by various segments of the allied animal industry. Readers of TAS will typically represent education, industry, and government, including research, teaching, administration, extension, management, quality assurance, product development, and technical services. Those interested in TAS typically include animal breeders, economists, embryologists, engineers, food scientists, geneticists, microbiologists, nutritionists, veterinarians, physiologists, processors, public health professionals, and others with an interest in animal production and applied aspects of animal sciences.

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