Gold Nanoparticle Synthesis and its Mode of Action as an Effective Therapy against Breast Carcinoma: Analysis of Traditional Methods and their Comparison with New Methods

Abstract

Breast cancer is one of the most widespread and lethal malignancies afflicting females globally. The global incidence of breast cancer is on the rise, with an anticipated 4.4 million cases by 2070. Notably, breast cancer constitutes approximately 25% of all cancer diagnoses. In the realm of biomedical sciences, nanotechnology has ushered in a transformative era, particularly in cancer therapy and diagnostics. Nanoparticles offer the capability to tailor specific sizes, with elevated surface-to-volume ratios proving advantageous for drug distribution by ensuring a substantial medicines loading volume. Gold nanoparticles exhibit a remarkable selectivity for cancer cells, primarily attributed to the heightened permeability and retaining effects. This study aims to assess the effectiveness of gold nanoparticles in breast cancer therapy, comparing them with traditional techniques from previous research and elucidating their mechanism of action. Data for analysis were sourced from various platforms, including Web of Science and Google Scholar, comprising previously published information. Analysis revealed that historical studies employed conventional techniques for breast cancer therapy. However, contemporary approaches now favor nanomedicine, incorporating diverse drugs and delivery systems, surpassing traditional methods. In summary, nanomedicine emerges as an exceptionally effective mode of breast cancer treatment when juxtaposed with conventional approaches. Previous research also underscores the efficacy of gold nanoparticles as a viable treatment modality. Currently, a spectrum of nanomedicines, including gold nanoparticles, serves as a promising avenue for suppressing tumor development in breast cancer patients