The expected changes with different periods of home-based resistance exercise in patients with chronic kidney disease

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Shu-Hua Chen, Ching-Ping Hsu, Hsiao-Hua Chang, Tai-Ju Liu, Fang-Ju Sun, Yao-Jen Liang
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Abstract

The comprehensive impact of prolonged home-based resistance training on individuals grappling with chronic kidney disease (CKD) have yet to be fully elucidated. This study aimed to explore the outcomes of varying exercise durations on physical performance, nutritional status, and kidney function within this specific population, encompassing patients undergoing dialysis and those affected by severe sarcopenia. This was a one-year observational double cohort study following a 52-week longitudinal design, we enrolled 101 adult CKD outpatients. These participants were divided into two groups: the continuous group, comprising individuals who consistently exercised for over six months, and the interrupted group, which included those who didn't sustain regular exercise for the same duration. The exercise regimen involved resistance exercises conducted at least 3 to 5 days per week, involving activities like lifting dumbbells and executing weighted wall squats. Physical activity assessments and biochemical blood tests were conducted at weeks 0, 4, 16, 28, 40, and 52 for all participants. The continuous exercise group exhibited better handgrip strength and sit-to-stand movement compared to the interrupted group. Their estimated glomerular filtration rate stayed steady while the interrupted group was declined. Additionally, those who exercised consistently had better metabolism: higher carbon dioxide levels, increased albumin, better nutritional scores, and lower levels of blood urea nitrogen, creatinine, fasting blood glucose, and body weight. Subsequent adjustments for potential confounding factors continued to show improved physical performance and kidney function over time. Our findings indicate the advantageous impact of extended resistance exercise training on overall health of CKD patients, even those on dialysis or with severe sarcopenia. Dedication to this exercise routine could improve kidney function, metabolism, and physical abilities in these patients.
慢性肾病患者在不同时期进行家庭阻力运动的预期变化
长期家庭阻力训练对慢性肾脏病(CKD)患者的综合影响尚未完全阐明。本研究旨在探讨不同运动持续时间对这一特殊人群(包括透析患者和严重肌肉疏松症患者)的体能表现、营养状况和肾功能的影响。 这是一项为期一年的观察性双队列研究,采用 52 周纵向设计,我们招募了 101 名成年慢性肾脏病门诊患者。这些参与者被分为两组:持续组和间断组,前者包括坚持锻炼超过六个月的人,后者包括没有坚持同样时间的定期锻炼的人。运动方案包括每周至少进行 3 到 5 天的抗阻力运动,涉及举哑铃和负重壁蹲等活动。在第 0 周、第 4 周、第 16 周、第 28 周、第 40 周和第 52 周,对所有参与者进行了体力活动评估和血液生化检测。 与间断运动组相比,持续运动组的手握力和坐立运动表现更好。他们的估计肾小球滤过率保持稳定,而间断组则有所下降。此外,持续运动组的新陈代谢更好:二氧化碳水平更高,白蛋白增加,营养评分更高,血尿素氮、肌酐、空腹血糖和体重水平更低。在对潜在的混杂因素进行调整后,随着时间的推移,身体表现和肾功能继续得到改善。 我们的研究结果表明,延长阻力运动训练对慢性肾脏病患者的整体健康具有有利影响,即使是那些正在透析或患有严重肌肉疏松症的患者也不例外。坚持这种锻炼方式可以改善这些患者的肾功能、新陈代谢和体能。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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