CLINICAL EVALUATION OF MESOTHERAPY ON THE IMPROVEMENT OF FACIAL SCARS (RANDOMIZED CONTROLLED CLINICAL TRIAL)

Abstract

INTRODUCTION: If a tissue's integrity has been compromised, most body tissues can go through wound healing and leave behind scars when they recover. Mesotherapy is a non-invasive transdermal injection into the skin which stimulating fibroblasts for collagen and elastin biosynthesis and facilitating cell-to-cell communication that can be used to heal face scars. OBJECTIVE: This study evaluated the efficacy of mesotherapy using both qualitative assessment and quantitative measurements in comparison to control group. MATERIALS AND METHODS: Twenty-four patients with oblique or vertical forehead lacerations who underwent primary closure within five days. Randomly divided into two groups: Group 1 (n=12) was given mesotherapy (microneedling) and group 2 (n=12) was given no further treatment. At the 1, 3, and 6-month follow-up appointments, the Vancouver scar scale (VSS) scores and wound diameter were assessed, along with clinical pictures and an assessment of the scar's pigmentation. RESULTS: At the 1-month follow-up, both groups had significantly improved. After 3 months, follow-up, the mesotherapy (microneedling) group displayed more significant changes in VSS, wound breadth, and color difference scores than the control group. Patients from both groups relapsed to their original records during the follow-up at 6 months. CONCLUSION: Significant progress was achieved in the VSS and in the wound width with Mesotherapy (microneedling) group compared to the control group. All the major changes were observed in the 3 and 6-month visits.