Factors related ART adherence and quality of life in PLHIV: Mediating role of positive self-care management and brain gym

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-08 DOI:10.29333/ejgm/14597

Nusalam Nursalam, Tintin Sukartini, Khatijah Lim Abdullah, Misutarno Misutarno, Idyatul Hasanah

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Abstract

Objectives: To investigate the factors affecting adherence to antiretroviral therapy (ART) and the quality of life in people living with human immunodeficiency virus (HIV), with a focus on evaluating the mediating roles of positive self-care management (PSCM) and brain gym. Methods: This is a descriptive study with a cross-sectional design. The data collected from June to August 2023. There are 262 respondents selected through convenience sampling. We used various research instruments, including questionnaires, which have undergone validity and reliability testing. The data were analyzed using the SEM-PLS analysis method. Results: Our data analysis shows that condition factors, physical and social environmental factors, and individual and family factors affect HIV individuals’ PSCM and brain gym combination, ART adherence, and quality of life. Findings show that condition-specific factors indirectly affect antiretroviral drug adherence. This impact is mediated by PSCM and brain gym. Conclusions: Specific condition variables, namely complexity of the disease, barriers, and stability of conditions indirectly influence ART adherence, mediated through the combined influence of PSCM and brain gym. This finding suggests that to enhance adherence and the quality of life among PLHIV, it is important to adopt an approach that encompasses a range of internal and external individual factors.

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艾滋病病毒感染者坚持抗逆转录病毒疗法和生活质量的相关因素：积极的自我护理管理和脑健身的中介作用

研究目的调查影响人类免疫缺陷病毒（HIV）感染者坚持抗逆转录病毒疗法（ART）和生活质量的因素，重点评估积极自我护理管理（PSCM）和大脑健身房的中介作用：这是一项横断面描述性研究。数据收集时间为 2023 年 6 月至 8 月。通过便利抽样法选取了 262 名受访者。我们使用了各种研究工具，包括经过有效性和可靠性测试的问卷。数据采用 SEM-PLS 分析方法进行分析：我们的数据分析显示，病情因素、物理和社会环境因素以及个人和家庭因素会影响 HIV 感染者的 PSCM 和脑健身组合、抗逆转录病毒疗法的依从性以及生活质量。研究结果表明，条件特异性因素会间接影响抗逆转录病毒药物的依从性。这种影响是由 PSCM 和脑力锻炼产生的：结论：特定条件变量，即疾病的复杂性、障碍和条件的稳定性，间接影响了抗逆转录病毒疗法的依从性，并通过 PSCM 和脑健身房的共同影响而产生中介作用。这一发现表明，要提高艾滋病毒感染者坚持抗逆转录病毒疗法的积极性和生活质量，必须采取一种涵盖一系列内外部个体因素的方法。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.