Plastin 3 Expression in Circulating Tumor Cells as a Predictor of Cancer Status in Patients with Prostate Cancer

IF 0.2 Q4 SURGERY

Formosan Journal of Surgery Pub Date : 2024-05-09 DOI:10.1097/fs9.0000000000000134

Meng-Hung Shih, Tai‐Lung Cha, Sheng‐Tang Wu, E. Meng, C. Tsao, C. Kao, Chin‐Li Chen, Yu-Ching Juho, Hui-Kung Ting, Guang‐Huan Sun, Sun‐Yran Chang, Dah-Shyong Yu, Ming‐Hsin Yang

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引用次数: 0

Abstract

To identify the role of plastin3 (PLS3) expression in circulating tumor cells (CTCs) of early stage prostate cancer (PCa). CTCs were collected from 23 prostate cancer patients based on cell surface markers targeting prostate cancer by V-BioChip. Condition of Plastin3 expression and correlations to the prostate cancer were also analyzed. Of the 23 patients with prostate cancer, total CTCs (CK+ or PLS3+) were found in 11 patients and PLS3+ CTCs were detected in 10 patients. When the cohort was stratified by risk group, 90% of the high-risk patients were found to have PLS3+ circulating tumor cells (9/10 patients). However, only 15.4% of low/intermediate-risk patients had PLS3+ circulating tumor cells (2/13 patients). The number of PLS3+ CTCs was higher in the high-risk group. The expression of PLS3 in CTCs is associated with prostate cancer risk. Further study of PLS3+ CTCs for prognosis prediction is required for clinical application in prostate cancer patients.

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循环肿瘤细胞中的 Plastin 3 表达可预测前列腺癌患者的癌症状况

旨在确定 plastin3 (PLS3) 在早期前列腺癌（PCa）循环肿瘤细胞（CTCs）中的表达作用。利用 V-BioChip 技术，根据针对前列腺癌的细胞表面标记物，收集 23 例前列腺癌患者的 CTCs。同时还分析了Plastin3的表达情况以及与前列腺癌的相关性。在 23 名前列腺癌患者中，11 名患者发现了总 CTC（CK+ 或 PLS3+），10 名患者发现了 PLS3+ CTC。按风险组别进行分层后，90% 的高危患者（9/10 例）发现了 PLS3+ 循环肿瘤细胞。然而，只有15.4%的低危/中危患者有PLS3+循环肿瘤细胞（2/13例）。高危组中 PLS3+ CTC 的数量更高。 CTC中PLS3的表达与前列腺癌风险有关。需要进一步研究 PLS3+ CTC 对前列腺癌患者预后预测的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Formosan Journal of Surgery SURGERY-

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： Formosan Journal of Surgery, a publication of Taiwan Surgical Association, is a peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s full text is available online at http://www.e-fjs.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.