Glycine/alginate-based piezoelectric film consisting of a single, monolithic β-glycine spherulite towards flexible and biodegradable force sensor

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Qiaoxia Lin, Yonggang Zhang, Luhua Chen, Haoyue Zhang, Chuanfeng An, Chengze Li, Qifan Wang, Jinhui Song, Wei He, Huanan Wang
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Abstract

Development of piezoelectric biomaterials with high piezoelectric performance, while possessing excellent flexibility, biocompatibility, and biodegradability still remains a great challenge. Herein, a flexible, biocompatible and biodegradable piezoelectric β-glycine-alginate-glycerol (Gly-Alg-Glycerol) film with excellent in vitro and in vivo sensing performance was developed. Remarkably, a single, monolithic β-glycine spherulite, instead of more commonly observed multiple spherulites, was formed in alginate matrix, thereby resulting in outstanding piezoelectric property, including high piezoelectric constant (7.2 pC/N) and high piezoelectric sensitivity (1.97 mV/kPa). The Gly-Alg-Glycerol film exhibited superior flexibility, enabling complex shape-shifting, e.g. origami pigeon, 40% tensile strain, and repeated bending and folding deformation without fracture. In vitro, the flexible Gly-Alg-Glycerol film sensor could detect subtle pulse signal, sound wave, and recognize shear stress applied from different directions. In addition, we have demonstrated that the Gly-Alg-Glycerol film sensor sealed by polylactic acid and beeswax could serve as an in vivo sensor to monitor physiological pressure signals such as heartbeat, respiration, and muscle movement. Finally, the Gly-Alg-Glycerol film possessed good biocompatibility, supporting the attachment and proliferation of rat mesenchymal stromal cells, and biodegradability, thereby showing great potential as biodegradable piezoelectric biomaterials for biomedical sensing applications.
基于甘氨酸/精氨酸的压电薄膜,由单片 β-甘氨酸球状石组成,用于柔性和可生物降解的力传感器
开发具有高压电性能,同时具有优异柔韧性、生物相容性和生物降解性的压电生物材料仍然是一项巨大的挑战。在此,我们开发了一种柔性、生物相容性和可生物降解的β-甘氨酸-精氨酸-甘油(Gly-Alg-Glycerol)压电薄膜,它具有优异的体外和体内传感性能。值得注意的是,在藻酸盐基质中形成了单一的、整体的 β-甘氨酸球粒,而不是通常观察到的多个球粒,因此具有出色的压电特性,包括高压电常数(7.2 pC/N)和高压电灵敏度(1.97 mV/kPa)。Gly-Alg-Glycerol 薄膜具有优异的柔韧性,可实现复杂的形状变换,如折纸鸽、40% 拉伸应变以及反复弯曲和折叠变形而不断裂。在体外,柔性甘氨酰甘油薄膜传感器可以检测到微妙的脉冲信号、声波,并能识别从不同方向施加的剪切应力。此外,我们还证明了由聚乳酸和蜂蜡密封的甘油-铝-甘油薄膜传感器可用作体内传感器,监测心跳、呼吸和肌肉运动等生理压力信号。最后,甘油-铝-甘油薄膜具有良好的生物相容性,可支持大鼠间充质基质细胞的附着和增殖,并具有生物可降解性,因此作为生物可降解压电生物材料在生物医学传感应用方面具有巨大潜力。
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
文献相关原料
公司名称
产品信息
索莱宝
Glycine
索莱宝
Triton X-100
索莱宝
Bovine serum albumin
麦克林
Sodium alginate
阿拉丁
Dichloromethane
阿拉丁
Chitosan
阿拉丁
Beeswax
阿拉丁
Glycerol
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