Evaluation of poly(2-hydroxyethyl methacrylate) and poly(N-hydroxyethyl acrylamide) cryogels as potential quercetin release matrices

IF 1.7 4区 工程技术 Q4 POLYMER SCIENCE
Cahit Özbilenler , Elvan Yilmaz , Ergül Mutlu Altundağ
{"title":"Evaluation of poly(2-hydroxyethyl methacrylate) and poly(N-hydroxyethyl acrylamide) cryogels as potential quercetin release matrices","authors":"Cahit Özbilenler ,&nbsp;Elvan Yilmaz ,&nbsp;Ergül Mutlu Altundağ","doi":"10.1080/1023666X.2024.2349628","DOIUrl":null,"url":null,"abstract":"<div><p>Fabrication of a suitable drug delivery system forms an attractive strategy to overcome the low bioavailability of quercetin. Poly(2-hydroxyethyl methacrylate–<em>co</em>-N-hydroxyethyl acrylamide), P(HEMA-<em>co</em>-HEAA) copolymer samples, and homopolymers of 2-hydroxyethyl methacrylate (PHEMA) and N-hydroxyethyl acrylamide (PHEAA) offer potential as quercetin delivery matrices owing to their favorable properties rendered in this study. Free radical polymerization applied under cryogenic conditions produced the polymer gels. The homopolymers and copolymers are noncytotoxic, porous, soft cryogels with surfaces resistant to protein and HCT-116 cancer cell adhesion. <em>In vitro,</em> quercetin release studies from samples reveal swelling-controlled, zero-order drug release at pH = 7.4 and 37 °C with high cumulative release percentages ranging from 92.03% to 94.82%. The durability of the cryogels and limited quercetin release at pH = 2.0 indicate that these cryogels are promising matrices for successfully delivering quercetin to the small intestine, where its primary absorption occurs.</p></div>","PeriodicalId":14236,"journal":{"name":"International Journal of Polymer Analysis and Characterization","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Polymer Analysis and Characterization","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1023666X24000143","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

Fabrication of a suitable drug delivery system forms an attractive strategy to overcome the low bioavailability of quercetin. Poly(2-hydroxyethyl methacrylate–co-N-hydroxyethyl acrylamide), P(HEMA-co-HEAA) copolymer samples, and homopolymers of 2-hydroxyethyl methacrylate (PHEMA) and N-hydroxyethyl acrylamide (PHEAA) offer potential as quercetin delivery matrices owing to their favorable properties rendered in this study. Free radical polymerization applied under cryogenic conditions produced the polymer gels. The homopolymers and copolymers are noncytotoxic, porous, soft cryogels with surfaces resistant to protein and HCT-116 cancer cell adhesion. In vitro, quercetin release studies from samples reveal swelling-controlled, zero-order drug release at pH = 7.4 and 37 °C with high cumulative release percentages ranging from 92.03% to 94.82%. The durability of the cryogels and limited quercetin release at pH = 2.0 indicate that these cryogels are promising matrices for successfully delivering quercetin to the small intestine, where its primary absorption occurs.

聚(2-羟乙基甲基丙烯酸酯)和聚(N-羟乙基丙烯酰胺)低温凝胶作为潜在槲皮素释放基质的评估
要克服槲皮素生物利用率低的问题,制造合适的给药系统是一项极具吸引力的策略。聚(2-羟乙基甲基丙烯酸酯-N-羟乙基丙烯酰胺)、P(HEMA-co-HEAA)共聚物样品以及 2-羟乙基甲基丙烯酸酯(PHEMA)和 N-羟乙基丙烯酰胺(PHEAA)的均聚物具有良好的性能,因此有可能成为槲皮素的给药基质。在低温条件下进行自由基聚合可产生聚合物凝胶。均聚物和共聚物是无细胞毒性、多孔、柔软的低温凝胶,其表面可抵抗蛋白质和 HCT-116 癌细胞的粘附。体外槲皮素释放研究表明,在 pH = 7.4 和 37 °C条件下,槲皮素受溶胀控制,药物零阶释放,累积释放率高达 92.03% 至 94.82%。低温凝胶的耐久性和在 pH = 2.0 时有限的槲皮素释放表明,这些低温凝胶是成功将槲皮素输送到小肠的理想基质,因为小肠是槲皮素的主要吸收途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.50
自引率
5.30%
发文量
37
审稿时长
1.6 months
期刊介绍: The scope of the journal is to publish original contributions and reviews on studies, methodologies, instrumentation, and applications involving the analysis and characterization of polymers and polymeric-based materials, including synthetic polymers, blends, composites, fibers, coatings, supramolecular structures, polysaccharides, and biopolymers. The Journal will accept papers and review articles on the following topics and research areas involving fundamental and applied studies of polymer analysis and characterization: Characterization and analysis of new and existing polymers and polymeric-based materials. Design and evaluation of analytical instrumentation and physical testing equipment. Determination of molecular weight, size, conformation, branching, cross-linking, chemical structure, and sequence distribution. Using separation, spectroscopic, and scattering techniques. Surface characterization of polymeric materials. Measurement of solution and bulk properties and behavior of polymers. Studies involving structure-property-processing relationships, and polymer aging. Analysis of oligomeric materials. Analysis of polymer additives and decomposition products.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信