Nose-to-brain Drug Delivery System: An Emerging Approach to Chemotherapy-induced Cognitive Impairment.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-05-14 DOI:10.2174/0122117385291482240426101519

Shireesha Jannapu Reddy, Srinivas Mutalik, G. L. Viswanatha, Gautam Kumar, Jeena John, M. Chamallamudi, Arpita Das, Sudip Das, K. Nandakumar

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Abstract

The rise in global cancer burden, notably breast cancer, emphasizes the need to address chemotherapy-induced cognitive impairment, also known as chemobrain. Although chemotherapy drugs are effective against cancer, they can trigger cognitive deficits. This has triggered the exploration of preventive strategies and novel therapeutic approaches. Nanomedicine is evolving as a promising tool to be used for the mitigation of chemobrain by overcoming the blood-brain barrier (BBB) with innovative drug delivery systems. Polymer and lipid-based nanoparticles enable targeted drug release, enhancing therapeutic effectiveness. Utilizing the intranasal route of administration may facilitate drug delivery to the central nervous system (CNS) by circumventing first-pass metabolism. Therefore, knowledge of nasal anatomy is critical for optimizing drug delivery via various pathways. Despite challenges, nanoformulations exhibit the potential in enhancing brain drug delivery. Continuous research into formulation techniques and chemobrain mechanisms is vital for developing effective treatments. The intranasal administration of nanoformulations holds promise for improving therapeutic outcomes in chemobrain management. This review offers insights into potential future research directions, such as exploring novel drug combinations, investigating alternative delivery routes, or integrating emerging technologies to enhance the efficacy and safety of nanoformulations for chemobrain management.

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鼻脑给药系统：治疗化疗引起的认知障碍的新方法

全球癌症（尤其是乳腺癌）发病率的上升凸显了解决化疗引起的认知障碍（又称化疗脑）问题的必要性。尽管化疗药物能有效抗癌，但也会引发认知障碍。这引发了人们对预防策略和新型治疗方法的探索。通过利用创新的药物输送系统克服血脑屏障 (BBB)，纳米医学正在发展成为一种用于缓解化疗脑的有前途的工具。以聚合物和脂质为基础的纳米颗粒可实现有针对性的药物释放，从而提高治疗效果。利用鼻内给药途径可以避开首过代谢，从而促进药物向中枢神经系统（CNS）的给药。因此，了解鼻腔解剖结构对于优化通过各种途径给药至关重要。尽管存在挑战，但纳米制剂在加强脑部给药方面仍有潜力。对制剂技术和化学脑机制的持续研究对于开发有效的治疗方法至关重要。纳米制剂的鼻内给药有望改善化脑治疗的疗效。本综述深入探讨了未来潜在的研究方向，如探索新型药物组合、研究替代给药途径或整合新兴技术，以提高纳米制剂在脑化学药物治疗中的疗效和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.