Nano-Formulation Approaches to Enhance Transdermal Drug Delivery-An Updated Review of Nanovesicular Carrier "Transethosomes".

Q2 Pharmacology, Toxicology and Pharmaceutics
Jitendra Pratap Singh, Geetanjali Saini, Gaurav Tiwari, Bhupendra Singh
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引用次数: 0

Abstract

Transdermal drug delivery is an attractive and patient-friendly route for administering therapeutic agents. However, the skin's natural barrier, the stratum corneum, restricts the passage of many drugs, limiting their effectiveness. To overcome this challenge, researchers have developed various nanocarriers to enhance drug penetration through the skin. Transethosomes, a novel and promising drug delivery system, have emerged as an innovative solution for improving transdermal drug delivery. Transethosomes are a hybrid of two established nanocarriers: ethosomes and transfersomes. Ethosomes are lipid-based vesicles that can accommodate lipophilic and hydrophilic drugs, while transfersomes are deformable lipid vesicles designed to enhance skin penetration. Transethosomes combine the advantages of both systems, making them ideal candidates for efficient transdermal drug delivery. They are composed of phospholipids, ethanol, and water and exhibit high flexibility, enabling them to squeeze through the tight junctions of the stratum corneum. This abstract reviews the key characteristics of transethosomes, including their composition, preparation methods, mechanisms of action, characterization parameters, and prospects. Moreover, the recent advancements and applications of transethosomes in delivering various therapeutic agents, such as analgesics, anti-inflammatories, hormones, and skincare products, are explored. The enhanced skin penetration capabilities of transethosomes can potentially reduce systemic side effects and improve patient compliance, making them a valuable tool in the field of transdermal drug delivery. In conclusion, transethosomes represent a promising platform for overcoming the challenges of transdermal drug delivery. Their unique properties enable efficient drug permeation through the skin, offering a more controlled and effective means of administering a wide range of pharmaceutical and cosmetic products. This abstract highlights the potential of transethosomes as a valuable addition to the field of transdermal drug delivery and paves the way for further research and development in this area.
增强透皮给药的纳米制剂方法--纳米囊状载体 "Transethosomes "的最新回顾。
透皮给药是一种极具吸引力且对患者友好的给药途径。然而,皮肤的天然屏障--角质层限制了许多药物的通过,从而限制了药物的有效性。为了克服这一难题,研究人员开发了各种纳米载体,以增强药物在皮肤中的渗透。透硫体是一种新型且前景广阔的给药系统,是改善透皮给药的创新解决方案。Transethosomes 是两种成熟纳米载体的混合体:ethosomes 和 transfersomes。乙硫体是基于脂质的囊泡,可容纳亲脂性和亲水性药物,而转移体是可变形的脂质囊泡,旨在增强皮肤渗透性。转运体结合了这两种系统的优点,是高效透皮给药的理想候选物质。它们由磷脂、乙醇和水组成,具有很高的柔韧性,能够挤压穿过角质层的紧密连接处。本摘要回顾了透硫体的主要特点,包括其组成、制备方法、作用机制、表征参数和前景。此外,摘要还探讨了最近在递送各种治疗剂(如镇痛剂、消炎药、激素和护肤品)方面跨硫体的进展和应用。透硫体具有更强的皮肤渗透能力,有可能减少全身副作用,提高患者的依从性,使其成为透皮给药领域的重要工具。总之,透硫体是克服透皮给药挑战的一个前景广阔的平台。它们的独特特性使药物能够高效地透过皮肤,为多种药物和化妆品的给药提供了一种更可控、更有效的方法。本摘要强调了透硫体作为透皮给药领域宝贵补充的潜力,并为该领域的进一步研究和开发铺平了道路。
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来源期刊
Pharmaceutical nanotechnology
Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
4.20
自引率
0.00%
发文量
46
期刊介绍: Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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