{"title":"Nuciferine Promotes Longevity and Fitness in Caenorhabditis elegans through the Regulation of the Insulin/IGF-1 Signaling Pathway","authors":"Yan Xu, Yuanxin Miao, Rong Li","doi":"10.1155/2024/2779989","DOIUrl":null,"url":null,"abstract":"<p>Nuciferine, as one of the most abundant plant-derived alkaloids, has multiple bioactivities including anti-inflammatory, antitumor, and lipid-lowering effects. Nevertheless, the antiaging effects and related mechanisms of nuciferine are rarely reported. In this study, we found that nuciferine significantly prolonged the mean lifespan of <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) by 14.86% at a dose of 100 <i>μ</i>M. Moreover, nuciferine promoted the health of <i>C. elegans</i> by increasing the body bending and pharyngeal pumping rates and reducing the lipofuscin accumulation level. Meanwhile, nuciferine enhanced stress tolerance by inducing the expression of stress-related genes or proteins. The molecular mechanism behind the antiaging effect of nuciferine occurred by downregulating the insulin/IGF-1 signaling (IIS) pathway. Our findings shed new light on the application of nuciferine for longevity promotion and human health.</p>","PeriodicalId":15802,"journal":{"name":"Journal of Food Biochemistry","volume":"2024 1","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Food Biochemistry","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/2024/2779989","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Nuciferine, as one of the most abundant plant-derived alkaloids, has multiple bioactivities including anti-inflammatory, antitumor, and lipid-lowering effects. Nevertheless, the antiaging effects and related mechanisms of nuciferine are rarely reported. In this study, we found that nuciferine significantly prolonged the mean lifespan of Caenorhabditis elegans (C. elegans) by 14.86% at a dose of 100 μM. Moreover, nuciferine promoted the health of C. elegans by increasing the body bending and pharyngeal pumping rates and reducing the lipofuscin accumulation level. Meanwhile, nuciferine enhanced stress tolerance by inducing the expression of stress-related genes or proteins. The molecular mechanism behind the antiaging effect of nuciferine occurred by downregulating the insulin/IGF-1 signaling (IIS) pathway. Our findings shed new light on the application of nuciferine for longevity promotion and human health.
期刊介绍：
The Journal of Food Biochemistry publishes fully peer-reviewed original research and review papers on the effects of handling, storage, and processing on the biochemical aspects of food tissues, systems, and bioactive compounds in the diet.
Researchers in food science, food technology, biochemistry, and nutrition, particularly based in academia and industry, will find much of great use and interest in the journal. Coverage includes:
-Biochemistry of postharvest/postmortem and processing problems
-Enzyme chemistry and technology
-Membrane biology and chemistry
-Cell biology
-Biophysics
-Genetic expression
-Pharmacological properties of food ingredients with an emphasis on the content of bioactive ingredients in foods
Examples of topics covered in recently-published papers on two topics of current wide interest, nutraceuticals/functional foods and postharvest/postmortem, include the following:
-Bioactive compounds found in foods, such as chocolate and herbs, as they affect serum cholesterol, diabetes, hypertension, and heart disease
-The mechanism of the ripening process in fruit
-The biogenesis of flavor precursors in meat
-How biochemical changes in farm-raised fish are affecting processing and edible quality
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