Vittoria Gammaldi, Anna Guida, C. Bologna, Antonietta De Sena, M. Lugará, Claudio De Luca, Fabio Granato Corigliano, Mariavittoria Guerra, Gabriella Oliva, Luca Mocerino, A. Zarrella, Maria Gabriella Coppola, Vincenzo Nuzzo, Paolo Tirelli, P. Madonna
{"title":"Acquired hemophilia A in a case of purple urine bag syndrome","authors":"Vittoria Gammaldi, Anna Guida, C. Bologna, Antonietta De Sena, M. Lugará, Claudio De Luca, Fabio Granato Corigliano, Mariavittoria Guerra, Gabriella Oliva, Luca Mocerino, A. Zarrella, Maria Gabriella Coppola, Vincenzo Nuzzo, Paolo Tirelli, P. Madonna","doi":"10.4081/itjm.2024.1713","DOIUrl":null,"url":null,"abstract":"The rare hemorrhagic disorder known as acquired hemophilia A (AHA) is brought on by the spontaneous development of autoantibodies against coagulation factor VIII (FVIII). It may be secondary to autoimmune diseases or cancers, or it may be idiopathic. Less than 10% of cases may have an infection as a secondary cause. We present the case of a 90-year-old anemic woman who was admitted to the hospital. She contracted a urinary tract infection (UTI) while in the hospital, and her urine took on a distinct purple hue. She had poor hemorrhagic manifestations and a prolonged partial thromboplastin time. After ruling out autoimmune and neoplastic causes, we diagnosed AHA as a result of a UTI caused by Enterococcus faecalis.","PeriodicalId":508241,"journal":{"name":"Italian Journal of Medicine","volume":"16 23","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Italian Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4081/itjm.2024.1713","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The rare hemorrhagic disorder known as acquired hemophilia A (AHA) is brought on by the spontaneous development of autoantibodies against coagulation factor VIII (FVIII). It may be secondary to autoimmune diseases or cancers, or it may be idiopathic. Less than 10% of cases may have an infection as a secondary cause. We present the case of a 90-year-old anemic woman who was admitted to the hospital. She contracted a urinary tract infection (UTI) while in the hospital, and her urine took on a distinct purple hue. She had poor hemorrhagic manifestations and a prolonged partial thromboplastin time. After ruling out autoimmune and neoplastic causes, we diagnosed AHA as a result of a UTI caused by Enterococcus faecalis.
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