Bimetallic Nanoparticles as Electrochemical Labels in Immunosensors for the Detection of Biomarkers of Clinical Interest

IF 3.4 Q2 CHEMISTRY, ANALYTICAL
David Valero-Calvo, Francisco Javier García-Alonso, Alfredo de la Escosura-Muñiz
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引用次数: 0

Abstract

Electrochemical immunosensors have emerged in the last years as outstanding analytical systems for the detection of analytes of clinical interest. As alternative to the traditional enzymatic labels, the use of nanoparticles and especially bimetallic ones has gained increased attention thanks to their advantages related to the higher simplicity, stability and sensitivity offered. Main routes for the detection of such nanoparticle labels are based on i) dissolution of the nanoparticle into the corresponding metal ions followed by voltammetric detection; ii) taking advantage of the electrocatalytic effect of the metals towards secondary reactions; and iii) taking advantage of their electrochemiluminescence properties.

Abstract Image

双金属纳米粒子作为免疫传感器中的电化学标签,用于检测临床相关的生物标记物
近年来,电化学免疫传感器已成为检测临床相关分析物的杰出分析系统。作为传统酶标记的替代品,纳米粒子,尤其是双金属纳米粒子的使用越来越受到关注,这是因为它们具有更简便、更稳定和更灵敏的优点。检测此类纳米粒子标签的主要方法有:i) 将纳米粒子溶解到相应的金属离子中,然后进行伏安检测;ii) 利用金属对二次反应的电催化效应;iii) 利用其电化学发光特性。在此背景下,本综述介绍了在免疫传感器中使用双金属纳米粒子作为电化学标签检测临床分析物的最新趋势。本综述介绍了在免疫传感器中使用双金属纳米粒子作为电化学标签检测临床感兴趣的分析物的最新趋势,并提供了分析性能和文献中发现的主要方法的重要概述,最后介绍了该领域的未来展望和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.60
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0.00%
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