Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-05-19 DOI:10.5498/wjp.v14.i5.653

Zhi-Wen Gu, Chun-Ping Zhang, Li-Ping Chen, Xiong Huang

{"title":"Clinical effects of nonconvulsive electrotherapy combined with mindfulness-based stress reduction and changes of serum inflammatory factors in depression","authors":"Zhi-Wen Gu, Chun-Ping Zhang, Li-Ping Chen, Xiong Huang","doi":"10.5498/wjp.v14.i5.653","DOIUrl":null,"url":null,"abstract":"BACKGROUND\n Depression is a common and serious psychological condition, which seriously affects individual well-being and functional ability. Traditional treatment methods include drug therapy and psychological counseling; however, these methods have different degrees of side effects and limitations. In recent years, nonconvulsive electrotherapy (NET) has attracted increasing attention as a noninvasive treatment method. However, the clinical efficacy and potential mechanism of NET on depression are still unclear. We hypothesized that NET has a positive clinical effect in the treatment of depression, and may have a regulatory effect on serum inflammatory factors during treatment.\n AIM\n To assess the effects of NET on depression and analyze changes in serum inflammatory factors.\n METHODS\n This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022, the observation group that received a combination of mindfulness-based stress reduction (MBSR) and NET treatment (n = 70) and the control group that only received MBSR therapy (n = 70). The clinical effectiveness of the treatment was evaluated by assessing various factors, including the Hamilton Depression Scale (HAMD)-17, self-rating idea of suicide scale (SSIOS), Pittsburgh Sleep Quality Index (PSQI), and levels of serum inflammatory factors before and after 8 wk of treatment. The quality of life scores between the two groups were compared. Comparisons were made using t and χ2 tests.\n RESULTS\n After 8 wk of treatment, the observation group exhibited a 91.43% overall effectiveness rate which was higher than that of the control group which was 74.29% (64 vs 52, χ2 = 7.241; P < 0.05). The HAMD, SSIOS, and PSQI scores showed a significant decrease in both groups. Moreover, the observation group had lower scores than the control group (10.37 ± 2.04 vs 14.02 ± 2.16, t = 10.280; 1.67 ±0.28 vs 0.87 ± 0.12, t = 21.970; 5.29 ± 1.33 vs 7.94 ± 1.35, t = 11.700; P both < 0.001). Additionally, there was a notable decrease in the IL-2, IL-1β, and IL-6 in both groups after treatment. Furthermore, the observation group exhibited superior serum inflammatory factors compared to the control group (70.12 ± 10.32 vs 102.24 ± 20.21, t = 11.840; 19.35 ± 2.46 vs 22.27 ± 2.13, t = 7.508; 32.25 ± 4.6 vs 39.42 ± 4.23, t = 9.565; P both < 0.001). Moreover, the observation group exhibited significantly improved quality of life scores compared to the control group (Social function: 19.25 ± 2.76 vs 16.23 ± 2.34; Emotions: 18.54 ± 2.83 vs 12.28 ± 2.16; Environment: 18.49 ± 2.48 vs 16.56 ± 3.44; Physical health: 19.53 ± 2.39 vs 16.62 ± 3.46; P both < 0.001) after treatment.\n CONCLUSION\n MBSR combined with NET effectively alleviates depression, lowers inflammation (IL-2, IL-1β, and IL-6), reduces suicidal thoughts, enhances sleep, and improves the quality of life of individuals with depression.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5498/wjp.v14.i5.653","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

BACKGROUND Depression is a common and serious psychological condition, which seriously affects individual well-being and functional ability. Traditional treatment methods include drug therapy and psychological counseling; however, these methods have different degrees of side effects and limitations. In recent years, nonconvulsive electrotherapy (NET) has attracted increasing attention as a noninvasive treatment method. However, the clinical efficacy and potential mechanism of NET on depression are still unclear. We hypothesized that NET has a positive clinical effect in the treatment of depression, and may have a regulatory effect on serum inflammatory factors during treatment. AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors. METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022, the observation group that received a combination of mindfulness-based stress reduction (MBSR) and NET treatment (n = 70) and the control group that only received MBSR therapy (n = 70). The clinical effectiveness of the treatment was evaluated by assessing various factors, including the Hamilton Depression Scale (HAMD)-17, self-rating idea of suicide scale (SSIOS), Pittsburgh Sleep Quality Index (PSQI), and levels of serum inflammatory factors before and after 8 wk of treatment. The quality of life scores between the two groups were compared. Comparisons were made using t and χ2 tests. RESULTS After 8 wk of treatment, the observation group exhibited a 91.43% overall effectiveness rate which was higher than that of the control group which was 74.29% (64 vs 52, χ2 = 7.241; P < 0.05). The HAMD, SSIOS, and PSQI scores showed a significant decrease in both groups. Moreover, the observation group had lower scores than the control group (10.37 ± 2.04 vs 14.02 ± 2.16, t = 10.280; 1.67 ±0.28 vs 0.87 ± 0.12, t = 21.970; 5.29 ± 1.33 vs 7.94 ± 1.35, t = 11.700; P both < 0.001). Additionally, there was a notable decrease in the IL-2, IL-1β, and IL-6 in both groups after treatment. Furthermore, the observation group exhibited superior serum inflammatory factors compared to the control group (70.12 ± 10.32 vs 102.24 ± 20.21, t = 11.840; 19.35 ± 2.46 vs 22.27 ± 2.13, t = 7.508; 32.25 ± 4.6 vs 39.42 ± 4.23, t = 9.565; P both < 0.001). Moreover, the observation group exhibited significantly improved quality of life scores compared to the control group (Social function: 19.25 ± 2.76 vs 16.23 ± 2.34; Emotions: 18.54 ± 2.83 vs 12.28 ± 2.16; Environment: 18.49 ± 2.48 vs 16.56 ± 3.44; Physical health: 19.53 ± 2.39 vs 16.62 ± 3.46; P both < 0.001) after treatment. CONCLUSION MBSR combined with NET effectively alleviates depression, lowers inflammation (IL-2, IL-1β, and IL-6), reduces suicidal thoughts, enhances sleep, and improves the quality of life of individuals with depression.

查看原文本刊更多论文

非抽搐电疗法与正念减压相结合的临床效果以及抑郁症患者血清炎症因子的变化

背景抑郁症是一种常见的严重心理疾病，严重影响个人的幸福感和工作能力。传统的治疗方法包括药物治疗和心理咨询，但这些方法都存在不同程度的副作用和局限性。近年来，非抽搐电疗法（NET）作为一种非侵入性治疗方法越来越受到人们的关注。然而，NET 对抑郁症的临床疗效和潜在机制仍不清楚。我们假设，NET 对治疗抑郁症有积极的临床效果，并可能在治疗过程中对血清炎症因子有调节作用。目的评估NET对抑郁症的影响，并分析血清炎症因子的变化。方法该回顾性研究共纳入了2017年5月至2022年6月期间接受抑郁症治疗的140例患者，观察组接受正念减压（MBSR）和NET联合治疗（n = 70），对照组仅接受MBSR治疗（n = 70）。通过评估各种因素，包括汉密尔顿抑郁量表（HAMD）-17、自杀意念自评量表（SSIOS）、匹兹堡睡眠质量指数（PSQI）以及治疗 8 周前后的血清炎症因子水平，来评估治疗的临床效果。对两组患者的生活质量评分进行比较。比较采用 t 和 χ2 检验。结果治疗 8 周后，观察组总有效率为 91.43%，高于对照组的 74.29%（64 vs 52，χ2 = 7.241；P < 0.05）。两组的 HAMD、SSIOS 和 PSQI 评分均显著下降。此外，观察组的得分低于对照组（10.37 ± 2.04 vs 14.02 ± 2.16，t = 10.280；1.67 ± 0.28 vs 0.87 ± 0.12，t = 21.970；5.29 ± 1.33 vs 7.94 ± 1.35，t = 11.700；P 均 < 0.001）。此外，治疗后两组的 IL-2、IL-1β 和 IL-6 均显著下降。此外，观察组的血清炎症因子优于对照组（70.12 ± 10.32 vs 102.24 ± 20.21，t = 11.840；19.35 ± 2.46 vs 22.27 ± 2.13，t = 7.508；32.25 ± 4.6 vs 39.42 ± 4.23，t = 9.565；P 均<0.001）。此外，与对照组相比，观察组的生活质量得分明显提高（社会功能：19.25 ± 2.76 vs 39.42 ± 4.23；P 均<0.001）：社会功能：19.25 ± 2.76 vs 16.23 ± 2.34；情绪：18.54 ± 2.83 vs 16.23 ± 2.34：18.54 ± 2.83 vs 12.28 ± 2.16；环境：环境：18.49 ± 2.48 vs 16.56 ± 3.44；身体健康：19.53 ± 2.39 vs 16.62 ± 3.46；P 均小于 0.001）。结论 MBSR结合NET能有效缓解抑郁，降低炎症（IL-2、IL-1β和IL-6），减少自杀念头，改善睡眠，提高抑郁症患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567