Prevalence and risk factors of depression among patients with perianal fistulizing Crohn’s disease

IF 3.9 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2024-05-19 DOI:10.5498/wjp.v14.i5.715

Jing Li, Wing-Yi Ng, Li-Chao Qiao, Fen Yuan, Xing Lan, Li-Bei Zhu, Bo-Lin Yang, Zhong-Qiu Wang

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Abstract

BACKGROUND Psychological distress, especially depression, associated with perianal fistulizing Crohn’s disease (PFCD) is widespread and refractory. However, there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with PFCD. AIM To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with PFCD. METHODS The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical staff. Depressive symptoms, life quality, and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9, Inflammatory Bowel Disease Patient Quality of Life Questionnaire (IBDQ), and Inflammatory Bowel Disease (IBD) Fatigue Patient Self-assessment Scale. The basic demographic information, overall disease features, perianal clinical information, and laboratory inflammation indicators were also gathered. Multivariate regression analysis was ultimately used to ascertain the risk factors of depression associated with PFCD. RESULTS A total of 123 patients with PFCD were involved, and 56.91% were suffering from depression. According to multivariate logistic regression analysis, Perianal Disease Activity Index (PDAI) score [odds ratio (OR) = 0.69, 95% confidence interval (CI): 0.50 to 0.95], IBDQ score (OR = 0.93, 95%CI: 0.88 to 0.97), modified Van Assche index (OR = 1.24, 95%CI: 1.01 to 1.53), and IBD Fatigue score (OR = 1.72, 95%CI: 1.23 to 2.42) were independent risk factors of depression-related prevalence among patients with PFCD (P < 0.05). Multiple linear regression analysis revealed that the increasing perianal modified Van Assche index (β value = 0.166, 95%CI: 0.02 to 0.31) and decreasing IBDQ score (β value = -0.116, 95%CI: -0.14 to -0.09) were independently associated with the severity of depression (P < 0.05). CONCLUSION Depressive symptoms in PFCD patients have significantly high prevalence. PDAI score, modified Van Assche index, quality of life, and fatigue severity were the main independent risk factors.

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肛瘘克罗恩病患者抑郁症的患病率和风险因素

背景与肛周瘘性克罗恩病（PFCD）相关的心理困扰，尤其是抑郁症，非常普遍且难以治愈。然而，迄今为止，试图确定与肛周瘘相关的抑郁症患病率和风险因素的研究却少得令人吃惊。目的估计全氟心肌梗死患者抑郁症状的患病率，并调查与抑郁症相关的风险因素。方法该研究通过问卷和专业医务人员以调查和临床数据收集的形式进行。通过患者健康问卷-9、炎症性肠病患者生活质量问卷（IBDQ）和炎症性肠病患者疲劳自评量表评估 PFCD 患者的抑郁症状、生活质量和疲劳严重程度。此外，还收集了基本人口统计学信息、总体疾病特征、肛周临床信息和实验室炎症指标。最终采用多变量回归分析来确定与全肛门慢性炎症相关的抑郁风险因素。结果共有 123 名 PFCD 患者，其中 56.91% 患有抑郁症。根据多变量逻辑回归分析，肛周疾病活动指数（PDAI）评分[几率比（OR）= 0.69，95% 置信区间（CI）：0.50 至 0.95]、IBDQ 评分（OR = 0.93，95%CI：0.88 至 0.97）、改良 Van Assche 指数（OR = 1.24，95%CI：1.01 至 1.53）和 IBD 疲劳评分（OR = 1.72，95%CI：1.23 至 2.42）是 PFCD 患者抑郁相关患病率的独立危险因素（P < 0.05）。多元线性回归分析显示，肛周改良范阿什指数的增加（β值=0.166，95%CI：0.02 至 0.31）和 IBDQ 评分的降低（β值=-0.116，95%CI：-0.14 至 -0.09）与抑郁症的严重程度独立相关（P < 0.05）。结论全肺结核患者抑郁症状的发生率明显较高。PDAI 评分、修改后的 Van Assche 指数、生活质量和疲劳严重程度是主要的独立风险因素。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.