Interstitial fluid flow decreases with age, especially after 50 years

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-05-19 DOI:10.1016/j.neurobiolaging.2024.05.006

Yuji Suzuki, Yukimi Nakamura, Hironaka Igarashi

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引用次数: 0

Abstract

Physiological age-related alterations in the interstitial flow in the brain, which plays an important role in waste product removal, remain unclear. Using [¹⁵O]H₂O positron emission tomography (PET), water dynamics were evaluated in 63 healthy adult participants aged between 20 and 80 years. Interstitial flow was assessed by influx ratio (IR) and drain rate (DR), using time-activity concentration data. Participants were divided into four age groups with 15-year ranges, to evaluate age-related functional alterations. At least one of the indices declined significantly with age across all groups. A significant linear negative correlation between age and both indicators was found in the scatter plots (IR: R² = 0.54, DR: R² = 0.44); both indicators were predominantly lower after age 50 years. These results suggest interstitial flow decreases with age, especially after 50 years. These important findings can contribute to devising therapeutic interventions for neurological diseases characterized by abnormal accumulation of waste products, and suggest the need for taking measures to maintain interstitial flow starting around the age of 50 years.

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随着年龄的增长，尤其是 50 岁以后，细胞间质的流动会减少

大脑中的间隙流在清除废物方面发挥着重要作用，但其与年龄有关的生理变化仍不清楚。研究人员使用[15O]H2O正电子发射断层扫描（PET）对 63 名年龄在 20 至 80 岁之间的健康成人进行了水动力学评估。利用时间-活动浓度数据，通过流入比（IR）和排出率（DR）对间质流量进行评估。研究人员被分为四个年龄组，每组 15 岁，以评估与年龄相关的功能变化。在所有组别中，随着年龄的增长，至少有一项指数会明显下降。在散点图中发现，年龄与这两项指标之间存在明显的线性负相关（IR：R2 = 0.54，DR：R2 = 0.44）；50 岁以后，这两项指标均明显下降。这些结果表明，随着年龄的增长，尤其是 50 岁以后，肺间质流量会减少。这些重要发现有助于针对以废物异常积累为特征的神经系统疾病制定治疗干预措施，并表明有必要从 50 岁左右开始采取措施维持间质流动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.