Advances in periodontal biomarkers.

Advances in clinical chemistry Pub Date : 2024-01-01 Epub Date: 2024-04-18 DOI:10.1016/bs.acc.2024.03.003
Ulvi Kahraman Gürsoy, Meltem Özdemir Kabalak, Mervi Gürsoy
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Abstract

Due to technologic advancements, periodontology has witnessed a boost in biomarker research over the past three decades. Indeed, with the aid of omics, our understanding of the healthy periodontium, pathogenesis of periodontal diseases, and healing after periodontal treatment has improved significantly. Yet, the traditional methods, periodontal probing and radiographies, remain the most common methods to diagnose periodontal disease and monitor treatment. Although these approaches can produce reliable diagnostic outcomes, they generally detect disease only after significant tissue degradation thus making treatment outcome highly uncertain. Accordingly, laboratories worldwide have collaborated with clinicians to design accurate, rapid and cost-effective biomarkers for periodontal disease diagnosis. Despite these efforts, biomarkers that can be widely used in early disease diagnosis and for treatment outcome prediction are far from daily use. The aim of this chapter is to give a general overview on periodontal health and diseases, and review recent advancements in periodontal biomarker research. A second aim will discuss the strengths and limitations of translating periodontal biomarker research to clinical practice. Genetic biomarkers of periodontitis are not discussed as the available confirmatory data is scarce.

牙周生物标志物的研究进展。
由于技术的进步,牙周病学在过去三十年里见证了生物标志物研究的发展。事实上,在全息技术的帮助下,我们对健康牙周、牙周疾病的发病机制以及牙周治疗后的愈合情况的了解有了显著提高。然而,牙周探诊和拍片等传统方法仍然是诊断牙周疾病和监测治疗的最常用方法。虽然这些方法可以产生可靠的诊断结果,但它们通常只有在组织严重退化后才会检测到疾病,因此治疗结果具有很大的不确定性。因此,世界各地的实验室与临床医生合作,设计出准确、快速、经济有效的牙周病诊断生物标志物。尽管做出了这些努力,但可广泛用于早期疾病诊断和治疗效果预测的生物标志物还远未被日常使用。本章旨在概述牙周健康和疾病,并回顾牙周生物标志物研究的最新进展。第二个目的是讨论将牙周生物标志物研究转化为临床实践的优势和局限性。由于现有的确证数据很少,因此本章不讨论牙周炎的遗传生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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