Mathematical modeling of brain metastases growth and response to therapies: A review

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-15 DOI:10.1016/j.mbs.2024.109207

Beatriz Ocaña-Tienda, Víctor M. Pérez-García

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引用次数: 0

Abstract

Brain metastases (BMs) are the most common intracranial tumor type and a significant health concern, affecting approximately 10% to 30% of all oncological patients. Although significant progress is being made, many aspects of the metastatic process to the brain and the growth of the resulting lesions are still not well understood. There is a need for an improved understanding of the growth dynamics and the response to treatment of these tumors. Mathematical models have been proven valuable for drawing inferences and making predictions in different fields of cancer research, but few mathematical works have considered BMs. This comprehensive review aims to establish a unified platform and contribute to fostering emerging efforts dedicated to enhancing our mathematical understanding of this intricate and challenging disease. We focus on the progress made in the initial stages of mathematical modeling research regarding BMs and the significant insights gained from such studies. We also explore the vital role of mathematical modeling in predicting treatment outcomes and enhancing the quality of clinical decision-making for patients facing BMs.

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脑转移瘤生长和对疗法反应的数学建模：综述。

脑转移（BMs）是最常见的颅内肿瘤类型，也是一个重要的健康问题，约占所有肿瘤患者的 10%至 30%。尽管取得了重大进展，但人们对脑转移过程的许多方面以及由此产生的病灶的生长情况仍不甚了解。我们需要进一步了解这些肿瘤的生长动态和对治疗的反应。事实证明，数学模型在不同癌症研究领域的推论和预测中都很有价值，但很少有数学著作考虑到脑转移瘤。这篇综合综述旨在建立一个统一的平台，促进新出现的致力于加强我们对这种错综复杂且具有挑战性的疾病的数学理解的研究。我们将重点关注有关 BMs 的数学建模研究在初始阶段所取得的进展，以及从这些研究中获得的重要启示。我们还探讨了数学建模在预测治疗结果和提高面临 BMs 患者的临床决策质量方面的重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.