Association of dietary iron intake with diabetic kidney disease among individuals with diabetes.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2024-09-01 Epub Date: 2024-05-17 DOI:10.1007/s12020-024-03819-y

Yichuan Wu, Manlu Xiao, Jiaqi Chen, Yuan Tao, Aomiao Chen, Huanjia Lin, Ying Xu, Linna Li, Hongxia Jia, Yaoming Xue, Yijie Jia, Zongji Zheng

{"title":"Association of dietary iron intake with diabetic kidney disease among individuals with diabetes.","authors":"Yichuan Wu, Manlu Xiao, Jiaqi Chen, Yuan Tao, Aomiao Chen, Huanjia Lin, Ying Xu, Linna Li, Hongxia Jia, Yaoming Xue, Yijie Jia, Zongji Zheng","doi":"10.1007/s12020-024-03819-y","DOIUrl":null,"url":null,"abstract":"Purpose: The current study investigated the correlation between dietary iron intake and diabetic kidney disease among diabetic adults.Methods: This cross-sectional study enrolled 8118 participants who suffered from diabetes from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Dietary iron intake was obtained from 24 h recall interviews, and diabetic kidney disease was defined as eGFR < 60 mL/min per 1.73 m2 or albumin creatinine ratio (ACR) ≥ 30 mg/g. Three weighted logistic regression models were utilized to investigate odd ratio (OR) and 95% CIs for diabetic kidney disease. Stratified analyses were performed by gender, age, BMI, HbA1c, hypertension status, and smoking status, and diabetes types.Results: Among 8118 participants (51.6% male, mean age 61.3 years), 40.7% of participants suffered from diabetic kidney disease. With the adjustment of potential covariates, we found that ≥ 12.59 mg of dietary iron was related to a lower risk of diabetic kidney disease (OR = 0.78, 95% CI: 0.63 to 0.96; OR = 0.79, 95% CI: 0.63 to 0.98). In stratified analyses, higher iron intake was negatively related to diabetic kidney disease, especially among those who were male, < 60 years, those with hypertension, those with HbA1c < 7.0%, and those who were ex-smokers. The result remained robust in sensitivity analyses.Conclusion: We found that ≥ 12.59 mg of dietary iron is associated with a lower risk of diabetic kidney disease, especially in those who were male, younger, heavier weight, have better blood sugar control, and those who were ex-smokers.","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-024-03819-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The current study investigated the correlation between dietary iron intake and diabetic kidney disease among diabetic adults.

Methods: This cross-sectional study enrolled 8118 participants who suffered from diabetes from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Dietary iron intake was obtained from 24 h recall interviews, and diabetic kidney disease was defined as eGFR < 60 mL/min per 1.73 m² or albumin creatinine ratio (ACR) ≥ 30 mg/g. Three weighted logistic regression models were utilized to investigate odd ratio (OR) and 95% CIs for diabetic kidney disease. Stratified analyses were performed by gender, age, BMI, HbA1c, hypertension status, and smoking status, and diabetes types.

Results: Among 8118 participants (51.6% male, mean age 61.3 years), 40.7% of participants suffered from diabetic kidney disease. With the adjustment of potential covariates, we found that ≥ 12.59 mg of dietary iron was related to a lower risk of diabetic kidney disease (OR = 0.78, 95% CI: 0.63 to 0.96; OR = 0.79, 95% CI: 0.63 to 0.98). In stratified analyses, higher iron intake was negatively related to diabetic kidney disease, especially among those who were male, < 60 years, those with hypertension, those with HbA1c < 7.0%, and those who were ex-smokers. The result remained robust in sensitivity analyses.

Conclusion: We found that ≥ 12.59 mg of dietary iron is associated with a lower risk of diabetic kidney disease, especially in those who were male, younger, heavier weight, have better blood sugar control, and those who were ex-smokers.

Abstract Image

查看原文本刊更多论文

糖尿病患者膳食铁摄入量与糖尿病肾病的关系。

目的：本研究调查了糖尿病成人膳食铁摄入量与糖尿病肾病之间的相关性：这项横断面研究从 1999-2018 年美国国家健康与营养调查（NHANES）中招募了 8118 名糖尿病患者。膳食铁摄入量通过24小时回忆访谈获得，糖尿病肾病定义为eGFR < 60 mL/min per 1.73 m2或白蛋白肌酐比值（ACR）≥ 30 mg/g。利用三个加权逻辑回归模型来研究糖尿病肾病的奇异比（OR）和 95% CI。根据性别、年龄、体重指数、HbA1c、高血压状况、吸烟状况和糖尿病类型进行了分层分析：在 8118 名参与者（51.6% 为男性，平均年龄 61.3 岁）中，40.7% 的参与者患有糖尿病肾病。在对潜在的协变量进行调整后，我们发现，膳食铁含量≥ 12.59 毫克与糖尿病肾病风险较低有关（OR = 0.78，95% CI：0.63 至 0.96；OR = 0.79，95% CI：0.63 至 0.98）。在分层分析中，较高的铁摄入量与糖尿病肾病呈负相关，尤其是在男性、年龄小于 60 岁、高血压患者和 HbA1c 结论患者中：我们发现，膳食铁摄入量≥ 12.59 毫克与糖尿病肾病风险较低有关，尤其是在男性、年轻、体重较重、血糖控制较好以及戒烟者中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.