Does glial lipid dysregulation alter sleep in Alzheimer's and Parkinson's disease?

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in molecular medicine Pub Date : 2024-10-01 Epub Date: 2024-05-15 DOI:10.1016/j.molmed.2024.04.010

Lindsey D Goodman, Matthew J Moulton, Guang Lin, Hugo J Bellen

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引用次数: 0

Abstract

In this opinion article, we discuss potential connections between sleep disturbances observed in Alzheimer's disease (AD) and Parkinson's disease (PD) and the dysregulation of lipids in the brain. Research using Drosophila has highlighted the role of glial-mediated lipid metabolism in sleep and diurnal rhythms. Relevant to AD, the formation of lipid droplets in glia, which occurs in response to elevated neuronal reactive oxygen species (ROS), is required for sleep. In disease models, this process is disrupted, arguing a connection to sleep dysregulation. Relevant to PD, the degradation of neuronally synthesized glucosylceramides by glia requires glucocerebrosidase (GBA, a PD-associated risk factor) and this regulates sleep. Loss of GBA in glia causes an accumulation of glucosylceramides and neurodegeneration. Overall, research primarily using Drosophila has highlighted how dysregulation of glial lipid metabolism may underlie sleep disturbances in neurodegenerative diseases.

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神经胶质脂质失调会改变阿尔茨海默氏症和帕金森氏症患者的睡眠吗？

在这篇观点文章中，我们讨论了在阿尔茨海默病（AD）和帕金森病（PD）中观察到的睡眠障碍与大脑脂质失调之间的潜在联系。利用果蝇进行的研究强调了神经胶质介导的脂质代谢在睡眠和昼夜节律中的作用。与注意力缺失症有关的是，神经胶质细胞中脂滴的形成是对神经元活性氧（ROS）升高的反应，是睡眠所必需的。在疾病模型中，这一过程会被破坏，从而证明与睡眠失调有关。与帕金森病有关的是，神经胶质细胞降解神经元合成的葡萄糖甘油酯需要葡萄糖脑苷脂酶（GBA，一种与帕金森病相关的风险因子），而葡萄糖脑苷脂酶调节睡眠。胶质细胞中葡萄糖脑苷脂酶（GBA）的缺失会导致葡萄糖甘油三酯的积累和神经变性。总之，主要利用果蝇进行的研究强调了神经胶质细胞脂质代谢失调可能是神经退行性疾病中睡眠障碍的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.