Oxytocin-Augmented Modular-Based Group Intervention for Loneliness: A Proof-Of-Concept Randomized Controlled Trial.

IF 16.3 1区 医学 Q1 PSYCHIATRY
Psychotherapy and Psychosomatics Pub Date : 2024-01-01 Epub Date: 2024-05-16 DOI:10.1159/000538752
Ruben Berger, Rene Hurlemann, Simone Shamay-Tsoory, Alisa Kanterman, Maura Brauser, Jessica Gorni, Maike Luhmann, Elisabeth Schramm, Johannes Schultz, Alexandra Philipsen, Jana Lieberz, Dirk Scheele
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Abstract

Introduction: Loneliness poses a significant health problem and existing psychological interventions have shown only limited positive effects on loneliness. Based on preliminary evidence for impaired oxytocin signaling in trait-like loneliness, the current proof-of-concept study used a randomized, double-blind, placebo-controlled design to probe intranasal oxytocin (OT) as an adjunct to a short-term modular-based group intervention for individuals suffering from high trait-like loneliness (HL, UCLA Loneliness Scale ≥55).

Methods: Seventy-eight healthy HL adults (56 women) received five weekly group psychotherapy sessions. HL participants received OT or placebo before the intervention sessions. Primary outcomes were trait-like loneliness measured at baseline, after the intervention, and again at two follow-up time points (3 weeks and 3 months), and, assessed at each session, state loneliness (visual analog scale), perceived stress (Perceived Stress Scale, PSS-10), quality of life (World Health Organization Five Well-Being Index, WHO-5), and the therapeutic relationship (Group Questionnaire, GQ-D).

Results: The psychological intervention was associated with significantly reduced perceived stress and improved trait-like loneliness across treatment groups, which was still evident at the 3-month follow-up. OT had no significant effect on trait-like loneliness, quality of life, or perceived stress. However, compared to placebo, OT significantly facilitated the decrease in state loneliness within sessions and significantly improved positive bonding between the group members.

Conclusion: Despite significantly improved trait-like loneliness after the intervention, OT did not significantly augment this effect. Further studies are needed to determine optimal intervention designs to translate the observed acute effects of OT into long-term benefits.

催产素增强模块化团体孤独干预:概念验证随机对照试验》。
引言孤独是一个严重的健康问题,现有的心理干预措施对孤独的积极影响有限。根据特质样孤独感中催产素信号受损的初步证据,目前的概念验证研究采用随机、双盲、安慰剂对照设计,探究鼻内催产素(OT)作为短期模块化团体干预的辅助手段,用于治疗高度特质样孤独感(HL,加州大学洛杉矶分校孤独感量表≥55)患者:78 名健康的 HL 成人(56 名女性)每周接受五次小组心理治疗。HL 参与者在干预课程前接受 OT 或安慰剂治疗。主要结果是在基线、干预后和两个随访时间点(3周和3个月)测量的特质孤独感,以及在每次治疗中评估的状态孤独感(视觉模拟量表)、感知压力(感知压力量表,PSS-10)、生活质量(世界卫生组织五项幸福指数,WHO-5)和治疗关系(团体问卷,GQ-D):结果:在各治疗组中,心理干预明显减轻了感知压力,改善了特质型孤独感,这在 3 个月的随访中仍很明显。心理治疗对特质型孤独感、生活质量或感知压力没有明显影响。然而,与安慰剂相比,加压疗法明显促进了疗程内状态孤独感的降低,并显著改善了小组成员之间的积极联系:结论:尽管干预后特质型孤独感有了明显改善,但加压疗法并没有明显增强这种效果。还需要进一步研究,以确定最佳干预设计,将观察到的加压疗法的急性效应转化为长期益处。
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来源期刊
Psychotherapy and Psychosomatics
Psychotherapy and Psychosomatics 医学-精神病学
CiteScore
29.40
自引率
6.10%
发文量
46
期刊介绍: Psychotherapy and Psychosomatics is a reputable journal that has been published since 1953. Over the years, it has gained recognition for its independence, originality, and methodological rigor. The journal has been at the forefront of research in psychosomatic medicine, psychotherapy research, and psychopharmacology, and has contributed to the development of new lines of research in these areas. It is now ranked among the world's most cited journals in the field. As the official journal of the International College of Psychosomatic Medicine and the World Federation for Psychotherapy, Psychotherapy and Psychosomatics serves as a platform for discussing current and controversial issues and showcasing innovations in assessment and treatment. It offers a unique forum for cutting-edge thinking at the intersection of medical and behavioral sciences, catering to both practicing clinicians and researchers. The journal is indexed in various databases and platforms such as PubMed, MEDLINE, Web of Science, Science Citation Index, Social Sciences Citation Index, Science Citation Index Expanded, BIOSIS Previews, Google Scholar, Academic Search, and Health Research Premium Collection, among others.
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