Recent Insights into the Roles of PEST-Containing Nuclear Protein.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biotechnology Pub Date : 2025-05-01 Epub Date: 2024-05-19 DOI:10.1007/s12033-024-01188-5

Shiyun Guo, Ruidong Ding, Qian Zhao, Xu Wang, Shuangyu Lv, Xin-Ying Ji

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引用次数: 0

Abstract

PEST-containing nuclear protein (PCNP), a short-lived small nuclear protein with 178 amino acids, is a nuclear protein containing two PEST sequences. PCNP is highly expressed in several malignant tumors such as cervical cancer, rectal cancer, and lung cancer. It is also associated with cell cycle regulation and the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and Wnt signaling pathways during tumor growth. The present article discuss how PCNP regulates the PI3K/AKT/mTOR and Wnt signaling pathways and related proteins, and the ubiquitination of PCNP regulates tumor cell cycle as well as the progress of the application of PCNP in the pathophysiology and treatment of colon cancer, human ovarian cancer, thyroid cancer, lung adenocarcinoma and oral squamous cell carcinoma. The main relevant articles were retrieved from PubMed, with keywords such as PEST-containing nuclear protein (PCNP), cancer (tumor), and signaling pathways as inclusion/exclusion criteria. Relevant references has been included and cited in the manuscript.

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对含 PEST 核蛋白作用的最新认识。

含 PEST 核蛋白（PCNP）是一种寿命很短的小型核蛋白，有 178 个氨基酸，是一种含有两个 PEST 序列的核蛋白。PCNP 在宫颈癌、直肠癌和肺癌等多种恶性肿瘤中高表达。它还与肿瘤生长过程中的细胞周期调控、磷酸肌酸 3- 激酶/蛋白激酶 B/哺乳动物雷帕霉素靶标（PI3K/AKT/mTOR）和 Wnt 信号通路有关。本文探讨了 PCNP 如何调控 PI3K/AKT/mTOR 和 Wnt 信号通路及相关蛋白，PCNP 泛素化如何调控肿瘤细胞周期，以及 PCNP 在结肠癌、人类卵巢癌、甲状腺癌、肺腺癌和口腔鳞癌的病理生理学和治疗中的应用进展。从 PubMed 上检索了主要相关文章，并以含 PEST 核蛋白（PCNP）、癌症（肿瘤）和信号通路等关键词作为纳入/排除标准。手稿中包含并引用了相关参考文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biotechnology 医学-生化与分子生物学

CiteScore

4.10

自引率

3.80%

发文量

165

审稿时长

6 months

期刊介绍： Molecular Biotechnology publishes original research papers on the application of molecular biology to both basic and applied research in the field of biotechnology. Particular areas of interest include the following: stability and expression of cloned gene products, cell transformation, gene cloning systems and the production of recombinant proteins, protein purification and analysis, transgenic species, developmental biology, mutation analysis, the applications of DNA fingerprinting, RNA interference, and PCR technology, microarray technology, proteomics, mass spectrometry, bioinformatics, plant molecular biology, microbial genetics, gene probes and the diagnosis of disease, pharmaceutical and health care products, therapeutic agents, vaccines, gene targeting, gene therapy, stem cell technology and tissue engineering, antisense technology, protein engineering and enzyme technology, monoclonal antibodies, glycobiology and glycomics, and agricultural biotechnology.