Maternal Risk Factors for Respiratory Syncytial Virus Lower Respiratory Tract Infection in Otherwise Healthy Preterm and Term Infants: A Systematic Review and Meta-analysis.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI:10.1097/INF.0000000000004387

Paolo Manzoni, Elsa Viora, Marcello Lanari, Raffaella Iantomasi, Eva Agostina Montuori, Barry Rodgers-Gray, Nicola Waghorne, Bianca Masturzo

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引用次数: 0

Abstract

Background/objective: To date, there is no published, formal assessment of all maternal risk factors for respiratory syncytial virus lower respiratory tract infection (RSV-LRTI) in infants. A systematic literature review and meta-analysis were undertaken to ascertain: What maternal risk factors are associated with an increased risk of RSV-LRTI in infants?

Methods: The systematic literature review used explicit methods to identify, select and analyze relevant data. PubMed, Embase and the Cochrane Library were searched (November 2022) using terms regarding: (1) RSV/LRTI; (2) risk factors; (3) pregnant/postpartum population. Bayesian meta-analysis compared RSV hospitalization (RSVH) risk in infants born to mothers with or without certain risk factors.

Results: A total of 2353 citations were assessed and 20 were included in the final review (10 individual studies; 10 pooled analyses). In 10 studies examining infants (<1 year) without comorbidities (primary outcome), 10 maternal risk factors were associated with RSV-LRTI/RSVH in multivariate analyses. Meta-analysis revealed smoking while pregnant increased infant RSVH risk by 2.01 (95% credible interval: 1.52-2.64) times, while breast-feeding was protective (0.73, 95% credible interval: 0.58-0.90). Risk scoring tools have reported that maternal risk factors contribute between 9% and 21% of an infant's total risk score for RSVH.

Conclusions: A greater understanding of maternal risk factors and their relative contribution to infant RSV-LRTI will enable more accurate assessments of the impact of preventive strategies.

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其他健康早产儿和足月儿呼吸道合胞病毒下呼吸道感染的母体风险因素：系统回顾与元分析》。

背景/目的：迄今为止，还没有对婴儿呼吸道合胞病毒下呼吸道感染（RSV-LRTI）的所有孕产妇风险因素进行正式评估的出版物。我们进行了系统的文献综述和荟萃分析，以确定哪些母亲风险因素与婴儿 RSV-LRTI 风险增加有关？系统性文献综述采用明确的方法来识别、选择和分析相关数据。使用以下术语对 PubMed、Embase 和 Cochrane 图书馆进行了检索（2022 年 11 月）：(1) RSV/LRTI；(2) 风险因素；(3) 怀孕/产后人群。贝叶斯荟萃分析比较了有或没有某些风险因素的母亲所生婴儿的 RSV 住院（RSVH）风险：结果：共评估了 2353 篇引文，20 篇被纳入最终综述（10 篇单独研究；10 篇汇总分析）。在 10 项研究中，对婴儿进行了调查（结论：进一步了解产妇风险因素及其对婴儿 RSV-LRTI 的相对影响，将有助于更准确地评估预防策略的影响。

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.