Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases.

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Targeting Pub Date : 2024-09-01 Epub Date: 2024-05-24 DOI:10.1080/1061186X.2024.2356736

Qi Wu, Jiangting Yao, Mengyun Xiao, Xiawei Zhang, Mengxiao Zhang, Xinting Xi

引用次数: 0

Abstract

Cardiovascular diseases (CVDs) are the leading cause of death globally, with oxidative stress (OS) identified as a primary contributor to their onset and progression. Given the elevated incidence and mortality rates associated with CVDs, there is an imperative need to investigate novel therapeutic strategies. Nuclear factor erythroid 2-related factor 2 (Nrf2), ubiquitously expressed in the cardiovascular system, has emerged as a promising therapeutic target for CVDs due to its role in regulating OS and inflammation. This review aims to delve into the mechanisms and actions of the Nrf2 pathway, highlighting its potential in mitigating the pathogenesis of CVDs.

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靶向 Nrf2 信号通路：心血管疾病的新治疗策略。

心血管疾病（CVDs）是导致全球死亡的主要原因，而氧化应激（OS）被认为是导致心血管疾病发病和恶化的主要因素。鉴于与心血管疾病相关的发病率和死亡率升高，研究新型治疗策略势在必行。核因子红细胞2相关因子2（Nrf2）在心血管系统中普遍表达，由于其在调节氧化应激和炎症方面的作用，它已成为心血管疾病的一个有希望的治疗靶点。本综述旨在深入探讨 Nrf2 通路的机制和作用，强调其在减轻心血管疾病发病机制方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.