A Unique Case of Mesenteric Gastrointestinal Stromal Tumor Presenting as an Acute Abdomen.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Lefika Bathobakae, Rammy Bashir, Sebastian Vera, Saif Yasin, Atang Koodirile, Ratul Bhattacharyya, Mehandar Kumar
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引用次数: 0

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract and arise from the interstitial cells of Cajal in the mesenteric plexus. These tumors can originate in any part of the GI tract; however, a higher burden has been observed in the stomach and small intestines. Mesenteric GISTs are exceedingly rare, with unique clinicopathological features and a poorer prognosis. Herein, we describe a unique case of a 66-year-old female with a remote history of appendectomy who presented to the emergency room complaining of severe abdominal pain and vomiting. On imaging, the patient was found to have a large inflammatory mass associated with small bowel loops, and the pathology confirmed a mesenteric GIST. The tumor was resected, and the genomic test results confirmed the KIT (exon 11) mutation. Although the tumor had a low mitotic rate, the tumor was large enough to warrant the initiation of adjuvant imatinib mesylate for 36 months with regular bloodwork and imaging.

以急性腹部为表现的肠系膜胃肠道间质瘤的独特病例
胃肠道间质瘤(GIST)是消化道中最常见的间质肿瘤,源于肠系膜丛中的卡贾尔间质细胞。这些肿瘤可起源于消化道的任何部位,但胃和小肠的发病率较高。肠系膜 GIST 极其罕见,具有独特的临床病理特征,预后较差。在此,我们描述了一例独特的病例:66 岁女性,曾有远期阑尾切除术史,因剧烈腹痛和呕吐到急诊就诊。影像学检查发现,患者有一个伴有小肠襻的巨大炎性肿块,病理证实为肠系膜 GIST。肿瘤被切除,基因组检测结果证实了 KIT(外显子 11)突变。虽然肿瘤的有丝分裂率很低,但肿瘤足够大,因此需要开始使用甲磺酸伊马替尼辅助治疗 36 个月,并定期进行血液检查和影像学检查。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
165
审稿时长
12 weeks
期刊介绍: The AFMR is committed to enhancing the training and career development of our members and to furthering its mission to facilitate the conduct of research to improve medical care. Case reports represent an important avenue for trainees (interns, residents, and fellows) and early-stage faculty to demonstrate productive, scholarly activity.
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